Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Sep;34(9):e457-e459.
doi: 10.1111/jdv.16613. Epub 2020 Jul 3.

Acute generalized exanthematous pustulosis with erythema multiforme-like lesions induced by Hydroxychloroquine in a woman with coronavirus disease 2019 (COVID-19)

E Robustelli Test  1 , P Vezzoli  2 , A Carugno  2 , F Raponi  2 , A Gianatti  3 , F Rongioletti  1 , P Sena  2
Affiliations
Case Reports

Acute generalized exanthematous pustulosis with erythema multiforme-like lesions induced by Hydroxychloroquine in a woman with coronavirus disease 2019 (COVID-19)

E Robustelli Test et al. J Eur Acad Dermatol Venereol. 2020 Sep.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Widespread acute rash on an erythematous–oedematous base, with scattered pinhead‐sized pustules involving the face, trunk and upper limbs; the patient is wearing a surgical mask and gloves in accordance with the hospital's anti‐coronavirus disease 2019 recommendations. (b) Extensive desquamation with scattered pustules on the abdomen and targetoid lesions on the thigh. (c) Erythematous–oedematous targetoid lesions covered by discrete small pustules and scales.
Figure 2
Figure 2
Subcorneal neutrophilic pustule, slight spongiosis with acanthosis, neutrophilic exocytosis, rare keratinocyte necrosis and a perivascular infiltrate consisting of lymphocytes with rare neutrophils and eosinophils (haematoxylin–eosin stain; original magnification: ×20).
See this image and copyright information in PMC

References

    1. Costanzo M, De Giglio MAR, Roviello GN. SARS‐CoV‐2: recent reports on antiviral therapies based on lopinavir/ritonavir, darunavir/umifenovir, hydroxychloroquine, remdesivir, favipiravir and other drugs for the treatment of the new coronavirus. Curr Med Chem 2020; 27. 10.2174/0929867327666200416131117. [Epub ahead of print]. - DOI - PubMed
    1. http://www.simit.org/medias/1569‐covid19‐vademecum‐13‐03‐202.pdf. (last accessed: 17 April 2020).
    1. Sidoroff A, Dunant A, Viboud C et al. Risk factors for acute generalized exanthematous pustulosis (AGEP)‐results of a multinational case‐control study (EuroSCAR). Br J Dermatol 2007; 157: 989–996. - PubMed
    1. Sharma AN, Mesinkovska NA, Paravar T. Characterizing the adverse dermatologic effects of hydroxychloroquine: a systematic review. J Am Acad Dermatol 2020; S0190‐9622(20)30564‐8. 10.1016/j.jaad.2020.04.024 [Epub ahead of print]. - DOI - PubMed
    1. Ghosn J, Duvivier C, Tubiana R, Katlama C, Caumes E. Acute generalized exanthematous pustulosis induced by HIV postexposure prophylaxis with lopinavir‐ritonavir. Clin Infect Dis 2005; 41: 1360–1361. - PubMed

Substances