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Review
. 2020 Jun:55:81-87.
doi: 10.1016/j.mib.2020.03.004. Epub 2020 May 7.

Metabolic control of virulence factor production in Staphylococcus aureus

Paulami Rudra  1 , Jeffrey M Boyd  2
Affiliations
Review

Metabolic control of virulence factor production in Staphylococcus aureus

Paulami Rudra et al. Curr Opin Microbiol. 2020 Jun.

Abstract

As investigators decipher the underlining mechanisms of Staphylococcus aureus pathogenesis, it is becoming apparent that perturbations in central metabolism alter virulence factor production and infection outcomes. It is also evident that S. aureus has the ability to metabolically adapt to improve colonization and overcome challenges imparted by the immune system. Altered metabolite pools modify virulence factor production suggesting that proper functioning of a core metabolic network is necessary for successful niche colonization and pathogenesis. Herein we discuss four examples of transcriptional regulators that monitor metabolic status. These regulatory systems sense perturbations in the metabolic network and respond by altering the transcription of genes utilized for central metabolism, energy generation and pathogenesis.

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Conflict of interest statement

Declaration of interests

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
Working model for CcpA-directed regulation of select genes in S. aureus.
Figure 2.
Figure 2.
Working model for PurR-directed regulation of select genes in S. aureus.
Figure 3.
Figure 3.
Working model for CodY-directed regulation of select genes in S. aureus.
Figure 4.
Figure 4.
Working model for SrrAB-directed regulation of select genes in S. aureus.
See this image and copyright information in PMC

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