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Comment
. 2020 May 14;41(19):1818-1820.
doi: 10.1093/eurheartj/ehaa414.

Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19

Gavin Y Oudit  1   2 , Marc A Pfeffer  3
Affiliations
Comment

Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19

Gavin Y Oudit et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
The role of ACE2 in controlling the renin–angiotensin system and the proteolytic shedding of membrane-bound ACE2 by ADAM-17. ACE2 converts Ang I and Ang II into Ang 1-9 and Ang 1-7, respectively, thereby negatively regulating the renin–angiotensin system (A). ACE2 serving as the receptor for the SARS-CoV-2 and activation of ADAM-17 by Ang II and SARS-CoV-2 binding leading to a loss of membrane-bound ACE2 attenuates a key homeostatic mechanism limiting Ang II effects in tissues, culminating in cardiovascular, renal, and lung diseases, key components of the heart failure syndrome (B). Higher plasma ACE2 levels were associated with male sex, history of atrial fibrillation, and coronary artery bypass graft, higher NYHA class, and heart rate; reduced ACE2 levels were associated with a history of chronic obstructive pulmonary diease, and higher left ventricular ejection fraction and systolic blood pressure (Sama et al.9). The dotted line indicates a putative role for ACE.
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