EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

Silvia Morbelli^{1

2}, Giuseppe Esposito³, Javier Arbizu⁴, Henryk Barthel⁵, Ronald Boellaard⁶, Nico I Bohnen⁷, David J Brooks^{8

9}, Jacques Darcourt¹⁰, John C Dickson¹¹, David Douglas¹², Alexander Drzezga^{13

14

15}, Jacob Dubroff¹⁶, Ozgul Ekmekcioglu¹⁷, Valentina Garibotto^{18

19}, Peter Herscovitch²⁰, Phillip Kuo²¹, Adriaan Lammertsma⁶, Sabina Pappata²², Iván Peñuelas⁴, John Seibyl²³, Franck Semah²⁴, Livia Tossici-Bolt²⁵, Elsmarieke Van de Giessen²⁶, Koen Van Laere²⁷, Andrea Varrone²⁸, Michele Wanner²⁹, George Zubal³⁰, Ian Law³¹

Affiliations

¹ IRCCS Ospedale Policlinico San Martino, Genoa, Italy. silvia.morbelli@unige.it.
² Nuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Department of Health Sciences, University of Genoa, Genoa, Italy. silvia.morbelli@unige.it.
³ Nuclear Medicine, Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Road NW CCC Bldg, Washington, DC, 20007, USA.
⁴ Department of Nuclear Medicine, University of Navarra, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain.
⁵ Department of Nuclear Medicine, Leipzig University, Leipzig, Germany.
⁶ Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, NeuroScience, De Boelelaan 1117, Amsterdam, The Netherlands.
⁷ Departments Radiology & Neurology, University of Michigan & Ann Arbor Veterans Medical Center, Ann Arbor, MI, USA.
⁸ Department of Nuclear Medicine, Aarhus University, Aarhus, Denmark.
⁹ Institute of Neuroscience, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
¹⁰ Nuclear Medicine, Department of imaging, Centre Antoine Lacassagne, Université Cote d'Azur, Nice, France.
¹¹ Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, UK.
¹² Department of Nuclear Medicine and Neuroradiology, Stanford University, Stanford, CA, USA.
¹³ Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
¹⁴ German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany.
¹⁵ Molecular Organization of the Brain, Research Center Jülich, Institute of Neuroscience and Medicine (INM-2), Jülich, Germany.
¹⁶ Division of Nuclear Medicine and Clinical Molecular Imaging in the Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
¹⁷ Department of Nuclear Medicine, Sisli Etfal Education and Research Hospital, Istanbul, Turkey.
¹⁸ NIMTLab, Faculty of Medicine, Geneva University, Geneva, Switzerland.
¹⁹ Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
²⁰ Positron Emission Tomography Department, NIH/CC, Bethesda, MD, USA.
²¹ Departments of Medical Imaging, Medicine and Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
²² National Council of Research, Institute of Biostructure and Bioimaging, Naples, Italy.
²³ Institute for Neurodegenerative Disorders, New Haven, USA.
²⁴ Nuclear Medicine Department, University Hospital, Lille, France.
²⁵ Medical Physics, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
²⁶ Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
²⁷ Nuclear Medicine and PET-MR Unit, Department of Imaging and Pathology, University Hospital and KU Leuven, Leuven, Belgium.
²⁸ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
²⁹ University of Washington, Seattle, WA, USA.
³⁰ Nuclear Medicine and CT, NIH/NIBIB, Bethesda, USA.
³¹ Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

PMID: 32388612
PMCID: PMC7300075
DOI: 10.1007/s00259-020-04817-8

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

Silvia Morbelli et al. Eur J Nucl Med Mol Imaging. 2020 Jul.

. 2020 Jul;47(8):1885-1912.

doi: 10.1007/s00259-020-04817-8. Epub 2020 May 9.

Authors

Affiliations

¹ IRCCS Ospedale Policlinico San Martino, Genoa, Italy. silvia.morbelli@unige.it.
² Nuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Department of Health Sciences, University of Genoa, Genoa, Italy. silvia.morbelli@unige.it.
³ Nuclear Medicine, Department of Radiology, Medstar Georgetown University Hospital, 3800 Reservoir Road NW CCC Bldg, Washington, DC, 20007, USA.
⁴ Department of Nuclear Medicine, University of Navarra, Clinica Universidad de Navarra, IdiSNA, Pamplona, Spain.
⁵ Department of Nuclear Medicine, Leipzig University, Leipzig, Germany.
⁶ Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, NeuroScience, De Boelelaan 1117, Amsterdam, The Netherlands.
⁷ Departments Radiology & Neurology, University of Michigan & Ann Arbor Veterans Medical Center, Ann Arbor, MI, USA.
⁸ Department of Nuclear Medicine, Aarhus University, Aarhus, Denmark.
⁹ Institute of Neuroscience, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
¹⁰ Nuclear Medicine, Department of imaging, Centre Antoine Lacassagne, Université Cote d'Azur, Nice, France.
¹¹ Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, UK.
¹² Department of Nuclear Medicine and Neuroradiology, Stanford University, Stanford, CA, USA.
¹³ Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
¹⁴ German Center for Neurodegenerative Diseases (DZNE), Bonn-Cologne, Germany.
¹⁵ Molecular Organization of the Brain, Research Center Jülich, Institute of Neuroscience and Medicine (INM-2), Jülich, Germany.
¹⁶ Division of Nuclear Medicine and Clinical Molecular Imaging in the Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
¹⁷ Department of Nuclear Medicine, Sisli Etfal Education and Research Hospital, Istanbul, Turkey.
¹⁸ NIMTLab, Faculty of Medicine, Geneva University, Geneva, Switzerland.
¹⁹ Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
²⁰ Positron Emission Tomography Department, NIH/CC, Bethesda, MD, USA.
²¹ Departments of Medical Imaging, Medicine and Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
²² National Council of Research, Institute of Biostructure and Bioimaging, Naples, Italy.
²³ Institute for Neurodegenerative Disorders, New Haven, USA.
²⁴ Nuclear Medicine Department, University Hospital, Lille, France.
²⁵ Medical Physics, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
²⁶ Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
²⁷ Nuclear Medicine and PET-MR Unit, Department of Imaging and Pathology, University Hospital and KU Leuven, Leuven, Belgium.
²⁸ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
²⁹ University of Washington, Seattle, WA, USA.
³⁰ Nuclear Medicine and CT, NIH/NIBIB, Bethesda, USA.
³¹ Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

PMID: 32388612
PMCID: PMC7300075
DOI: 10.1007/s00259-020-04817-8

Abstract

Purpose: This joint practice guideline or procedure standard was developed collaboratively by the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI). The goal of this guideline is to assist nuclear medicine practitioners in recommending, performing, interpreting, and reporting the results of dopaminergic imaging in parkinsonian syndromes.

Methods: Currently nuclear medicine investigations can assess both presynaptic and postsynaptic function of dopaminergic synapses. To date both EANM and SNMMI have published procedural guidelines for dopamine transporter imaging with single photon emission computed tomography (SPECT) (in 2009 and 2011, respectively). An EANM guideline for D2 SPECT imaging is also available (2009). Since the publication of these previous guidelines, new lines of evidence have been made available on semiquantification, harmonization, comparison with normal datasets, and longitudinal analyses of dopamine transporter imaging with SPECT. Similarly, details on acquisition protocols and simplified quantification methods are now available for dopamine transporter imaging with PET, including recently developed fluorinated tracers. Finally, [¹⁸F]fluorodopa PET is now used in some centers for the differential diagnosis of parkinsonism, although procedural guidelines aiming to define standard procedures for [¹⁸F]fluorodopa imaging in this setting are still lacking.

Conclusion: All these emerging issues are addressed in the present procedural guidelines for dopaminergic imaging in parkinsonian syndromes.

Keywords: Brain; DAT; DOPA; PET; Parkinson; Parkinsonian syndromes; SPECT.

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Conflict of interest statement

Silvia Morbelli has received speaker honoraria from GE Healthcare and Eli-Lilly; Javier Arbizu has received research grants from Lilly-Avid, General Electric Healthcare, and Piramal and speaker honoraria from Biogen, Araclon Biotech-Grifols, Bayer, and Novartis; Ronald Boellaard has provided data analysis service for Bristol Meyers Squibb, Rodin, and Roche and is a scientific advisor for EARL; Nico Bohnen has received research support from the NIH, Department of Veteran Affairs, the Michael J. Fox Foundation, Eisai, Axovant Sciences, and Chase Pharmaceuticals; David Brooks was consultant for GE Healthcare and Biogen; John C. Dickson was consultant for GE Healthcare, Bioclinica, and Biogen; Alexander Drzezga has received speaker honoraria from Siemens Healthineers, Sanofi, and Henning and received research support from AVID/Lilly, Life Molecular Imaging, GE Healthcare, and Siemens Healthineers; Jacob Dubroff received speaker honoraria from IBA; Peter Herscovitch is a member of Medical Imaging Drug Advisory Committee of US Food and Drug Administration; John Seibyl is consultant for Invicro, Biogen, Roche, Life Molecular Imaging, and LikeMinds and has equity holding of Invicro; K. Van Laere has performed consultancy services and contract research, through KU Leuven, for GE Healthcare, Merck, Janssen Pharmaceuticals, UCB, Syndesi Therapeutics, and Eikonizo; Ian Law has received speaker honoraria from Siemens Healthcare. The other authors declare no conflict of interest.

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EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

Affiliations

EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources