Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep;24(6):e13724.
doi: 10.1111/petr.13724. Epub 2020 May 10.

Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience

Fatina I Fadel  1   2 , Hafez M Bazaraa  1   2 , Hesham Badawy  3 , Hany A Morsi  3 , Gamal Saadi  4 , Mohamed A Abdel Mawla  5 , Amr Mohamed Salem  1   2 , Eman Abobakr Abd Alazem  1 , Rasha Helmy  1   2 , Mohamed Gamal Fathallah  1   2 , Yasmin Ramadan  1   2 , Yosra Aboelnaga Fahmy  1   2 , Shaimaa Sayed  1   2 , Eman Fathy Eryan  1   2 , Fatma Mohammad Atia  1   2 , Mohamed ElGhonimy  3 , Ahmed I Shoukry  3 , Ahmed M Shouman  3 , Waleed Ghonima  3 , Mohamed Salah Eldin  3 , Sherif M Soaida  6 , Wesam Ismail  7 , Doaa M Salah  1   2
Affiliations

Pediatric kidney transplantation in Egypt: Results of 10-year single-center experience

Fatina I Fadel et al. Pediatr Transplant. 2020 Sep.

Abstract

Pediatric kidney transplantation is a multidisciplinary therapy that needs special consideration and experience. In this study, we aimed to present CUCH experience; over a 10-year period, as a specialized center of kidney transplantation in children. We studied 148 transplantations performed at a single center from 2009 to 2018. Pretransplant and follow-up data were collected and graft/patient survival rates were evaluated. A total of 48 patients developed at least one rejection episode during 688 patient-years of follow-up. Infections, recurrence of original disease, and malignancy were the most important encountered medical complications (20%, 2%, and 1.4%, respectively). One-year patient survival was 94.1%, while graft and patient survival was 91.9%. Graft/patient survival at 5, 7, and 9 years was 90%, 77%, and 58%, respectively. Infections were the main cause (69%) of mortality. Death with a functioning graft and CR were the main causes of graft loss (48% and 33%, respectively). Pediatric kidney transplantation in Egypt is still a challenging yet successful experience. Rejections and infections are the most frequent complications. Short-term outcomes surpass long-term ones and graft survival rates are similar to the international standard.

Keywords: immunosuppressive therapy; infection; rejection; renal replacement therapy; transplantation outcome.

PubMed Disclaimer

References

REFERENCES

    1. Kaspar CDW, Bholah R, Bunchman TEA. Review of pediatric chronic kidney disease. Blood Purif. 2016;41:211-217.
    1. Safouh H, Fadel F, Essam R, Salah A, Bekhet A. Causes of chronic kidney disease in Egyptian children. Saudi J Kidney Dis Transpl. 2015;26(4):806-809.
    1. Rees L. Long-term outcome after renal transplantation in childhood. Pediatr Nephrol. 2009;24(3):475-484.
    1. Dharnidharka VR, Fiorina P, Harmon WE. Kidney transplantation in children. N Engl J Med. 2014;371:549-558.
    1. Torkaman M, Khalili-Matin-Zadeh Z, Azizabadi-Farahani M, et al Outcome of living kidney transplant: pediatric in comparison to adults. Transplant Proc. 2007;39:1088-1090.