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Review
. 2020 Jul;245(13):1122-1129.
doi: 10.1177/1535370220924618. Epub 2020 May 9.

The WWOX gene in brain development and pathology

K Kośla  1 , Ż Kałuzińska  1 , A K Bednarek  1
Affiliations
Review

The WWOX gene in brain development and pathology

K Kośla et al. Exp Biol Med (Maywood). 2020 Jul.

Abstract

WW domain-containing oxidoreductase encoded by the WWOX gene is a transcription regulator and a key player in a number of cellular and biological processes such as tumor suppression, cell proliferation, apoptosis induction, steroid metabolism, and central nervous system development. This review provides a comprehensive summary of currently known roles and discusses the importance of WWOX gene for CNS development and functioning.

Keywords: WW domain-containing oxidoreductase; WWOX; glioblastoma; infantile encephalopathy; neurodegeneration; neurodifferentiation; neurogenesis.

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Figures

Figure 1.
Figure 1.
Pleiotropic role of WWOX in the development and function of the central nervous system, with an indication of interactions with known protein partners. (A color version of this figure is available in the online journal.)
Figure 2.
Figure 2.
The WWOX involvement in neuronal cells differentiation and maintenance. (A color version of this figure is available in the online journal.)
See this image and copyright information in PMC

References

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