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Review
. 2020 Sep;21(9):e13045.
doi: 10.1111/obr.13045. Epub 2020 May 10.

NLRP3 sparks the Greek fire in the war against lipid-related diseases

Shuai Jiang  1 , Haoxiang Xiao  2 , Zhen Wu  1 , Zhi Yang  1 , Baoping Ding  1 , Zhenxiao Jin  2 , Yang Yang  1
Affiliations
Review

NLRP3 sparks the Greek fire in the war against lipid-related diseases

Shuai Jiang et al. Obes Rev. 2020 Sep.

Abstract

In recent years, the obesity rate worldwide has reached epidemic proportions and contributed to the growing prevalence of lipid-related diseases. A strong link between inflammation and metabolism is becoming increasingly evident. Compelling evidence has indicated the activation of the nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome, a cytoplasmic complex containing multiple proteins, in a variety of lipid-related diseases including obesity, atherosclerosis, liver diseases, and type 2 diabetes. Recent studies have further clarified the regulatory mechanisms and the optional therapeutic agents that target NLRP3 inflammasomes. In this study, we review the recent progress in the research on NLRP3 inflammasomes and discuss their implications for a better understanding of inflammation in lipid-related disease and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.

Keywords: NLRP3 inflammasome; atherosclerosis; lipid-related diseases; liver diseases; obesity; type 2 diabetes.

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References

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