Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr 24:8:261.
doi: 10.3389/fcell.2020.00261. eCollection 2020.

Cancer Radiotherapy: Understanding the Price of Tumor Eradication

Olga A Martin  1 , Roger F Martin  2
Affiliations

Cancer Radiotherapy: Understanding the Price of Tumor Eradication

Olga A Martin et al. Front Cell Dev Biol. .
No abstract available

Keywords: DNA damage; DNA repair; aging; cancer radiotherapy; normal tissue toxicity; quality of life; radioprotectors; systemic effects.

PubMed Disclaimer

Figures

Figure 1
Figure 1
RT amplifies processes reminiscent the biological hallmarks of aging.
See this image and copyright information in PMC

References

    1. Azzam E. I., Jay-Gerin J. P., Pain D. (2012). Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett. 327, 48–60. 10.1016/j.canlet.2011.12.012 - DOI - PMC - PubMed
    1. Barnett G. C., West C. M., Dunning A. M., Elliott R. M., Coles C. E., Pharoah P. D., et al. (2009). Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat. Rev. Cancer. 9, 134–142. 10.1038/nrc2587 - DOI - PMC - PubMed
    1. Baskar R., Lee K. A., Yeo R., Yeoh K. W. (2012). Cancer and radiation therapy: current advances and future directions. Int. J. Med. Sci. 9, 193–199. 10.7150/ijms.3635 - DOI - PMC - PubMed
    1. Bodgi L., Foray N. (2016). The nucleo-shuttling of the ATM protein as a basis for a novel theory of radiation response: resolution of the linear-quadratic model. Int. J. Radiat. Biol. 92, 117–131. 10.3109/09553002.2016.1135260 - DOI - PubMed
    1. Burdak-Rothkamm S., Smith A., Lobachevsky P., Martin R., Prise K. M. (2015). Radioprotection of targeted and bystander cells by methylproamine. Strahl. Onkol. 191, 248–255. 10.1007/s00066-014-0751-9 - DOI - PMC - PubMed