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Case Reports
. 2020 May 25;49(2):240-244.
doi: 10.3785/j.issn.1008-9292.2020.03.08.

[Pregnant women complicated with COVID-19: a clinical analysis of 3 cases]

[Article in Chinese]
Xu Chen  1 , Yang Li  1 , Jinxi Wang  1 , Hongliu Cai  2 , Hongcui Cao  3 , Jifang Sheng  3
Affiliations
Case Reports

[Pregnant women complicated with COVID-19: a clinical analysis of 3 cases]

[Article in Chinese]
Xu Chen et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Objective: To analyze the clinical characteristics and pregnancy outcomes of pregnant women complicated with coronavirus disease 2019 (COVID-19).

Methods: The clinical data of 3 pregnant women with COVID-19 admitted to the First Affiliated Hospital of Zhejiang University School of Medicine from January 19 to February 10, 2020 were retrospectively analyzed.

Results: There was one case in the first-trimester pregnancy (case 1), one in the second-trimester pregnancy (case 2) and one in third-trimester pregnancy (case 3). Cough, fever, fatigue, lung imaging changes were the main manifestations. The white cell count, lymphocyte percentage had no significantly changes in case 1 and case 3, while the levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), IL-6 and IL-10 elevated. The lymphocyte count and lymphocyte percentage decreased and the inflammatory indicators significantly increased in case 2. All patients were treated with antiviral, antitussive, oxygen inhalation; case 3 received glucocorticoids, case 2 with severe illness received glucocorticoids and additionally gamma globulin. All three cases were cured and discharged. Case 1 with early pregnancy chose to terminate pregnancy after discharge; case 2 chose to continue pregnancy without obstetric complications; and case 3 had cesarean section delivery due to abnormal fetal heart monitoring.

Conclusions: The report shows that COVID-19 in pregnancy women could be cured with active treatment, and the maternal and fetal outcomes can be satisfactory.

目的: 研究妊娠合并2019冠状病毒病（COVID-19）患者的临床特点及妊娠结局。

方法: 对浙江大学医学院附属第一医院2020年1月19日至2月10日收治的3例妊娠合并COVID-19患者的临床表现、辅助检查、治疗经过、妊娠结局进行回顾性分析。

结果: 3例患者早孕（例1）、中孕（例2）、晚孕（例3）各1例，例1和例3为COVID-19普通型，例2为COVID-19重型；以咳嗽、发热、乏力、肺部影像学改变为主要表现，例1、例3实验室检查提示白细胞计数、淋巴细胞百分比等无明显变化，炎症指标如C反应蛋白、红细胞沉降率、IL-6、IL-10等轻度升高，例2淋巴细胞计数及淋巴细胞百分比明显降低，炎症因子水平明显升高。3例患者经过抗病毒、止咳、吸氧等综合治疗，其中例2使用糖皮质激素和丙种球蛋白调节免疫治疗，例3使用糖皮质激素，均符合出院标准。例1出院后选择终止妊娠；例2无产科并发症选择继续妊娠；例3因胎心监护异常行剖宫产终止妊娠，母胎情况良好。

结论: 妊娠合并COVID-19患者经积极治疗可以痊愈，母胎结局良好，但对子代的影响仍需进一步研究。

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Figures

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图1
3例妊娠合并COVID-19患者入院时肺部CT表现
See this image and copyright information in PMC

References

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