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. 2020 Aug;86(8):1452-1453.
doi: 10.1111/bcp.14320. Epub 2020 May 11.

Metformin disposition-A 40-year-old mystery

Geoffrey T Tucker  1 , Carl A Wesolowski  2
Affiliations

Metformin disposition-A 40-year-old mystery

Geoffrey T Tucker et al. Br J Clin Pharmacol. 2020 Aug.
No abstract available

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References

    1. Wikipedia.org/wiki/Metformin.
    1. Pentikainen PJ, Neuvonen OJ, Penttila A. Pharmacokinetics of metformin after intravenous and oral administration in man. Eur J Clin Pharmacol. 1979;16(3):195‐202. - PubMed
    1. Sirtori CR, Franceschini G, Galli‐Kienle M, et al. Disposition of metformin (N,N‐dimethylbiguanide) in man. Clin Pharmacol Ther. 1978;24(6):683‐693. - PubMed
    1. Tucker GT, Casey C, Phillips PJ, Connor H, Ward JD, Woods HF. Metformin kinetics in healthy subjects and in patients with diabetes mellitus. Br J Clin Pharmacol. 1981;12(2):235‐246. - PMC - PubMed
    1. Poursat BAJ, van Spanning RJM, Braster M, Helmus R, de Voogt P, Parsons JR. Biodegradation of metformin and its transformation product, guanylurea, by natural and exposed microbial communities. Ecotoxicol Environ Saf. 2019;182:109414. - PubMed