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Case Reports
. 2020 Sep 15;202(6):890-893.
doi: 10.1164/rccm.202002-0252LE.

A Unique Case of Secondary Pulmonary Alveolar Proteinosis after E-Cigarette, or Vaping, Product Use-associated Lung Injury

Anna-Karoline Israel  1 , Moises J Velez  1 , Serban A Staicu  1 , Robert Ambrosini  1 , Matthew McGraw  1 , Tanupriya Agrawal  1
Affiliations
Case Reports

A Unique Case of Secondary Pulmonary Alveolar Proteinosis after E-Cigarette, or Vaping, Product Use-associated Lung Injury

Anna-Karoline Israel et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Frontal chest X-ray with bilateral perihilar hazy air space opacification. (B) High-resolution chest computed tomographic scan showing interlobular septal thickening forming a crazy paving pattern. (C) Hematoxylin and eosin showing extracellular eosinophilic hyaline material (arrow). (D) Periodic acid–Schiff with diastase–positive extracellular globular material. (E) Periodic acid–Schiff with diastase–positive granular deposit in intracytoplasmic macrophages (arrow). (F) Oil red O stain highlighting intracytoplasmic (macrophages) lipid vacuoles. (G) Oil red O stain–positive extracellular hyaline globules. (C–G) Scale bars, 20 μm. (H) Electron microscopy showing myelin-like whorled membranous structures (lamellar bodies) (scale bar, 0.5 μm).
See this image and copyright information in PMC

Comment in

References

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    1. Layden JE, Ghinai I, Pray I, Kimball A, Layer M, Tenforde MW, et al. Pulmonary illness related to E-cigarette use in Illinois and Wisconsin - final report. N Engl J Med. 2020;382:903–916. - PubMed
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    1. Triantafyllou GA, Tiberio PJ, Zou RH, Lamberty PE, Lynch MJ, Kreit JW, et al. Vaping-associated acute lung injury: a case series. Am J Respir Crit Care Med. 2019;200:1430–1431. - PubMed

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