doi: 10.1021/acs.joc.9b03505.
Epub 2020 May 11.
Metal-Free Trifluoroalkylation of Quinoxalin-2(1 H)-ones with Unactivated Alkenes and Langlois' Reagent
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- PMID: 32392413
- DOI: 10.1021/acs.joc.9b03505
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Metal-Free Trifluoroalkylation of Quinoxalin-2(1 H)-ones with Unactivated Alkenes and Langlois' Reagent
J Org Chem.
.
Abstract
A K2S2O8-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1H)-ones under metal-free conditions. The present reaction could be accomplished through the trifluoroalkylation of quinoxalin-2(1H)-ones with unactivated alkenes and Langlois' reagent (CF3SO2Na), which provided a highly attractive approach to access a series of biologically important 3-trifluoroalkylated quinoxalin-2(1H)-ones.
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