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. 2020 Jun 5;85(11):6888-6896.
doi: 10.1021/acs.joc.9b03505. Epub 2020 May 11.

Metal-Free Trifluoroalkylation of Quinoxalin-2(1 H)-ones with Unactivated Alkenes and Langlois' Reagent

Na Meng  1 , Leilei Wang  1 , Qishun Liu  1 , Qinyu Li  1 , Yufen Lv  1 , Huilan Yue  1 , Xiaojuan Wang  2 , Wei Wei  1   3
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Metal-Free Trifluoroalkylation of Quinoxalin-2(1 H)-ones with Unactivated Alkenes and Langlois' Reagent

Na Meng et al. J Org Chem. .

Abstract

A K2S2O8-mediated three-component protocol has been developed for the construction of 3-trifluoroalkylated quinoxalin-2(1H)-ones under metal-free conditions. The present reaction could be accomplished through the trifluoroalkylation of quinoxalin-2(1H)-ones with unactivated alkenes and Langlois' reagent (CF3SO2Na), which provided a highly attractive approach to access a series of biologically important 3-trifluoroalkylated quinoxalin-2(1H)-ones.

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