Are Human Dendrites Different?

Mehmet Fişek¹, Michael Häusser²

Affiliations

¹ Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK; Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
² Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK; Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: m.hausser@ucl.ac.uk.

PMID: 32392467
PMCID: PMC7903140
DOI: 10.1016/j.tics.2020.03.002

Comment

Are Human Dendrites Different?

Mehmet Fişek et al. Trends Cogn Sci. 2020 Jun.

. 2020 Jun;24(6):411-412.

doi: 10.1016/j.tics.2020.03.002. Epub 2020 Mar 30.

Authors

Mehmet Fişek¹, Michael Häusser²

Affiliations

¹ Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK; Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK.
² Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK; Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: m.hausser@ucl.ac.uk.

PMID: 32392467
PMCID: PMC7903140
DOI: 10.1016/j.tics.2020.03.002

Abstract

The first patch-clamp recordings from the dendrites of human neocortical neurons have recently been reported by Beaulieu-Laroche et al. and Gidon et al. These studies have shown that human dendrites are electrically excitable, exhibiting backpropagating action potentials and fast dendritic calcium spikes. This new frontier highlights the potential for interspecies differences in the biophysics of dendritic computation.

Keywords: cortex; dendrite; human; neural computation; patch clamp; pyramidal cell; rodent; synaptic integration.

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Enhanced Dendritic Compartmentalization in Human Cortical Neurons.
Beaulieu-Laroche L, Toloza EHS, van der Goes MS, Lafourcade M, Barnagian D, Williams ZM, Eskandar EN, Frosch MP, Cash SS, Harnett MT. Beaulieu-Laroche L, et al. Cell. 2018 Oct 18;175(3):643-651.e14. doi: 10.1016/j.cell.2018.08.045. Cell. 2018. PMID: 30340039 Free PMC article.
Dendritic action potentials and computation in human layer 2/3 cortical neurons.
Gidon A, Zolnik TA, Fidzinski P, Bolduan F, Papoutsi A, Poirazi P, Holtkamp M, Vida I, Larkum ME. Gidon A, et al. Science. 2020 Jan 3;367(6473):83-87. doi: 10.1126/science.aax6239. Science. 2020. PMID: 31896716

References

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1. Molnár G. Complex events initiated by individual spikes in the human cerebral cortex. PLoS Biol. 2008;6 - PMC - PubMed

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Are Human Dendrites Different?

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Are Human Dendrites Different?

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