Management of the neurologically deceased organ donor: A Canadian clinical practice guideline

Ian M Ball¹, Laura Hornby², Bram Rochwerg², Matthew J Weiss², Clay Gillrie², Michaël Chassé², Frederick D'Aragon², Maureen O Meade², Karim Soliman², Aadil Ali², Samantha Arora², John Basmaji², J Gordon Boyd², Bernard Cantin², Prosanto Chaudhury², Marcelo Cypel², Darren Freed², Anne Julie Frenette², Pam Hruska², Constantine J Karvellas², Sean Keenan², Andreas Kramer², Demetrios James Kutsogiannis², Dale Lien², Patrick Luke², Meagan Mahoney², Jeffrey M Singh², Lindsay C Wilson², Alissa Wright², Jeffrey Zaltzman², Sam D Shemie²

Affiliations

¹ Departments of Medicine (Ball), Internal Medicine (Basmaji) and Surgery (Luke), Western University, London, Ont.; Children's Hospital of Eastern Ontario Research Institute (Hornby); Deceased Donation (Hornby, Shemie, Wilson), Canadian Blood Services, Ottawa, Ont.; Department of Medicine (Division of Critical Care) and Department of Health Research Methods, Evidence and Impact (Rochwerg, Meade), McMaster University, Hamilton, Ont.; Faculté de médecine (Weiss), Université Laval; Transplant Quebec (Weiss), Québec, Que.; Canadian Blood Services (Gillrie), Ottawa, Ont.; Department of Medicine and School of Public Health (Chassé), University of Montreal, Montréal, Que.; Department of Anesthesiology, Faculty of Medicine and Health Sciences (D'Aragon), University of Sherbrooke, Sherbrooke, Que.; Critical Care (Soliman), Queen's University, Kingston, Ont.; Latner Thoracic Surgery Research Laboratories, Institute of Medical Sciences (Ali), University of Toronto, Toronto, Ont.; Northern Ontario School of Medicine (Arora), Thunder Bay, Ont.; Department of Medicine (Neurology) and Critical Care, Centre for Neuroscience Studies (Boyd), Queen's University, Kingston, Ont.; Department of Medicine (Cantin), Université Laval, Québec, Que.; Gerald Bronfman Department of Oncology (Cantin), McGill University, Montréal, Que.; Departments of Surgery (Cypel) and Medicine (Singh), University of Toronto, Toronto, Ont.; Division of Cardiac Surgery (Freed), University of Alberta, Edmonton, Alta.; Faculty of Pharmacy (Frenette), University of Montreal, Montréal, Que.; Alberta Health Services (Hruska), Calgary, Alta.; Department of Critical Care Medicine (Karvellas), University of Alberta, Edmonton, Alta.; BC Transplant (Keenan), Vancouver, BC; Division of Critical Care (Keenan), University of British Columbia, Vancouver, BC; Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute (Kramer), University of Calgary, Calgary, Alta.; Faculty of Medicine and Dentistry (Kutsogiannis), University of Alberta, Edmonton, Alta.; Department of Medicine (Lien), University of Alberta, Edmonton, Alta.; London Health Sciences Centre (Luke), London, Ont.; Department of Pediatrics (Mahoney), University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Wright), University of British Columbia, Vancouver, BC; Division of Nephrology (Zaltzman), University of Toronto, Toronto, Ont.; Department of Pediatrics (Shemie), McGill University, Montréal, Que. Ian.Ball@lhsc.on.ca.
² Departments of Medicine (Ball), Internal Medicine (Basmaji) and Surgery (Luke), Western University, London, Ont.; Children's Hospital of Eastern Ontario Research Institute (Hornby); Deceased Donation (Hornby, Shemie, Wilson), Canadian Blood Services, Ottawa, Ont.; Department of Medicine (Division of Critical Care) and Department of Health Research Methods, Evidence and Impact (Rochwerg, Meade), McMaster University, Hamilton, Ont.; Faculté de médecine (Weiss), Université Laval; Transplant Quebec (Weiss), Québec, Que.; Canadian Blood Services (Gillrie), Ottawa, Ont.; Department of Medicine and School of Public Health (Chassé), University of Montreal, Montréal, Que.; Department of Anesthesiology, Faculty of Medicine and Health Sciences (D'Aragon), University of Sherbrooke, Sherbrooke, Que.; Critical Care (Soliman), Queen's University, Kingston, Ont.; Latner Thoracic Surgery Research Laboratories, Institute of Medical Sciences (Ali), University of Toronto, Toronto, Ont.; Northern Ontario School of Medicine (Arora), Thunder Bay, Ont.; Department of Medicine (Neurology) and Critical Care, Centre for Neuroscience Studies (Boyd), Queen's University, Kingston, Ont.; Department of Medicine (Cantin), Université Laval, Québec, Que.; Gerald Bronfman Department of Oncology (Cantin), McGill University, Montréal, Que.; Departments of Surgery (Cypel) and Medicine (Singh), University of Toronto, Toronto, Ont.; Division of Cardiac Surgery (Freed), University of Alberta, Edmonton, Alta.; Faculty of Pharmacy (Frenette), University of Montreal, Montréal, Que.; Alberta Health Services (Hruska), Calgary, Alta.; Department of Critical Care Medicine (Karvellas), University of Alberta, Edmonton, Alta.; BC Transplant (Keenan), Vancouver, BC; Division of Critical Care (Keenan), University of British Columbia, Vancouver, BC; Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute (Kramer), University of Calgary, Calgary, Alta.; Faculty of Medicine and Dentistry (Kutsogiannis), University of Alberta, Edmonton, Alta.; Department of Medicine (Lien), University of Alberta, Edmonton, Alta.; London Health Sciences Centre (Luke), London, Ont.; Department of Pediatrics (Mahoney), University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Wright), University of British Columbia, Vancouver, BC; Division of Nephrology (Zaltzman), University of Toronto, Toronto, Ont.; Department of Pediatrics (Shemie), McGill University, Montréal, Que.

PMID: 32392524
PMCID: PMC7145376
DOI: 10.1503/cmaj.190631

Practice Guideline

Management of the neurologically deceased organ donor: A Canadian clinical practice guideline

Ian M Ball et al. CMAJ. 2020.

. 2020 Apr 6;192(14):E361-E369.

doi: 10.1503/cmaj.190631.

Authors

Affiliations

¹ Departments of Medicine (Ball), Internal Medicine (Basmaji) and Surgery (Luke), Western University, London, Ont.; Children's Hospital of Eastern Ontario Research Institute (Hornby); Deceased Donation (Hornby, Shemie, Wilson), Canadian Blood Services, Ottawa, Ont.; Department of Medicine (Division of Critical Care) and Department of Health Research Methods, Evidence and Impact (Rochwerg, Meade), McMaster University, Hamilton, Ont.; Faculté de médecine (Weiss), Université Laval; Transplant Quebec (Weiss), Québec, Que.; Canadian Blood Services (Gillrie), Ottawa, Ont.; Department of Medicine and School of Public Health (Chassé), University of Montreal, Montréal, Que.; Department of Anesthesiology, Faculty of Medicine and Health Sciences (D'Aragon), University of Sherbrooke, Sherbrooke, Que.; Critical Care (Soliman), Queen's University, Kingston, Ont.; Latner Thoracic Surgery Research Laboratories, Institute of Medical Sciences (Ali), University of Toronto, Toronto, Ont.; Northern Ontario School of Medicine (Arora), Thunder Bay, Ont.; Department of Medicine (Neurology) and Critical Care, Centre for Neuroscience Studies (Boyd), Queen's University, Kingston, Ont.; Department of Medicine (Cantin), Université Laval, Québec, Que.; Gerald Bronfman Department of Oncology (Cantin), McGill University, Montréal, Que.; Departments of Surgery (Cypel) and Medicine (Singh), University of Toronto, Toronto, Ont.; Division of Cardiac Surgery (Freed), University of Alberta, Edmonton, Alta.; Faculty of Pharmacy (Frenette), University of Montreal, Montréal, Que.; Alberta Health Services (Hruska), Calgary, Alta.; Department of Critical Care Medicine (Karvellas), University of Alberta, Edmonton, Alta.; BC Transplant (Keenan), Vancouver, BC; Division of Critical Care (Keenan), University of British Columbia, Vancouver, BC; Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute (Kramer), University of Calgary, Calgary, Alta.; Faculty of Medicine and Dentistry (Kutsogiannis), University of Alberta, Edmonton, Alta.; Department of Medicine (Lien), University of Alberta, Edmonton, Alta.; London Health Sciences Centre (Luke), London, Ont.; Department of Pediatrics (Mahoney), University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Wright), University of British Columbia, Vancouver, BC; Division of Nephrology (Zaltzman), University of Toronto, Toronto, Ont.; Department of Pediatrics (Shemie), McGill University, Montréal, Que. Ian.Ball@lhsc.on.ca.
² Departments of Medicine (Ball), Internal Medicine (Basmaji) and Surgery (Luke), Western University, London, Ont.; Children's Hospital of Eastern Ontario Research Institute (Hornby); Deceased Donation (Hornby, Shemie, Wilson), Canadian Blood Services, Ottawa, Ont.; Department of Medicine (Division of Critical Care) and Department of Health Research Methods, Evidence and Impact (Rochwerg, Meade), McMaster University, Hamilton, Ont.; Faculté de médecine (Weiss), Université Laval; Transplant Quebec (Weiss), Québec, Que.; Canadian Blood Services (Gillrie), Ottawa, Ont.; Department of Medicine and School of Public Health (Chassé), University of Montreal, Montréal, Que.; Department of Anesthesiology, Faculty of Medicine and Health Sciences (D'Aragon), University of Sherbrooke, Sherbrooke, Que.; Critical Care (Soliman), Queen's University, Kingston, Ont.; Latner Thoracic Surgery Research Laboratories, Institute of Medical Sciences (Ali), University of Toronto, Toronto, Ont.; Northern Ontario School of Medicine (Arora), Thunder Bay, Ont.; Department of Medicine (Neurology) and Critical Care, Centre for Neuroscience Studies (Boyd), Queen's University, Kingston, Ont.; Department of Medicine (Cantin), Université Laval, Québec, Que.; Gerald Bronfman Department of Oncology (Cantin), McGill University, Montréal, Que.; Departments of Surgery (Cypel) and Medicine (Singh), University of Toronto, Toronto, Ont.; Division of Cardiac Surgery (Freed), University of Alberta, Edmonton, Alta.; Faculty of Pharmacy (Frenette), University of Montreal, Montréal, Que.; Alberta Health Services (Hruska), Calgary, Alta.; Department of Critical Care Medicine (Karvellas), University of Alberta, Edmonton, Alta.; BC Transplant (Keenan), Vancouver, BC; Division of Critical Care (Keenan), University of British Columbia, Vancouver, BC; Departments of Critical Care Medicine and Clinical Neurosciences, Hotchkiss Brain Institute (Kramer), University of Calgary, Calgary, Alta.; Faculty of Medicine and Dentistry (Kutsogiannis), University of Alberta, Edmonton, Alta.; Department of Medicine (Lien), University of Alberta, Edmonton, Alta.; London Health Sciences Centre (Luke), London, Ont.; Department of Pediatrics (Mahoney), University of Calgary, Calgary, Alta.; Division of Infectious Diseases (Wright), University of British Columbia, Vancouver, BC; Division of Nephrology (Zaltzman), University of Toronto, Toronto, Ont.; Department of Pediatrics (Shemie), McGill University, Montréal, Que.

PMID: 32392524
PMCID: PMC7145376
DOI: 10.1503/cmaj.190631

No abstract available

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Conflict of interest statement

Competing interests: John Gordon Boyd reports receiving salary support from the Trillium Gift of Life Network, nonfinancial support from Caster Medical and a grant from Physician Services Incorporated, outside the submitted work. Maureen Meade reports receiving a knowledge translation grant from Canadian Blood Services, and salary support as a hospital donation physician for Trillium Gift of Life Network. Matthew J Weiss reports receiving ongoing funding from Transplant Québec for his work as medical director of organ donation. Karim Soliman reports receiving a stipend to support education in the province from the Trillium Gift of Life Network. Jeffrey Singh reports receiving a salary as the regional medical lead for donation at Trillium Gift of Life Network. Samantha Arora reports receiving a knowledge translation grant from Canadian Blood Services, and salary support for Hospital Donation Physician work with Trillium Gift of Life, outside the submitted work. Ian Ball reports receiving a consultant stipend from Trillium Gift of Life Network for work as a donation physician. Sam Shemie reports receiving salary support as a medical advisor for deceased organ donation, Canadian Blood Services. Laura Hornby reports receiving consulting fees from Canadian Blood Services. Prosanto Chaudhury reports receiving a salary as a medical director of Transplant Québec, and receiving honoraria from Novartis, Ipsen and Amgen for participation in advisory boards and for hosting invited speakers, outside the submitted work. Alissa Wright reports receiving a stipend for work as an Infectious Disease consultant for BC Transplant. Sean Keenan reports receiving ongoing funding for his work as Provincial Medical Director for BC Transplant. No other competing interests were declared.

References

1. Organ donation and transplantation in Canada: system progress report — 2017 update. Ottawa: Canadian Blood Services; 2018. Available: https://blood.ca/sites/default/files/System_Progress_Report_2017_Update_... (accessed 2019 Feb. 10).
1. Shemie SD, Ross H, Pagliarello J, et al. Organ donor management in Canada: recommendations of the forum on medical management to optimize donor organ potential. CMAJ 2006;174:S13–32. - PMC - PubMed
1. Kotloff RM, Blosser S, Fulda GJ, et al. Management of the potential organ donor in the ICU: Society of Critical Care Medicine/American College of Chest Physicians/ Association of Organ Procurement Organizations Consensus Statement. Crit Care Med 2015;43:1291–325. - PubMed
1. Ellis MKM, Sally MB, Malinoski DJ. Management of the potential organ donor. In: Salim A, Brown C, Inaba K, et al., editors. Surgical critical care therapy: a clinically oriented practical approach. Cham (Switzerland): Springer International Publishing; 2018:67–75.
1. Pandit RA, Zirpe KG, Gurav SK, et al. Management of potential organ donor: Indian Society of Critical Care Medicine: position statement. Indian J Crit Care Med 2017;21:303–16. - PMC - PubMed

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Management of the neurologically deceased organ donor: A Canadian clinical practice guideline

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Management of the neurologically deceased organ donor: A Canadian clinical practice guideline

Authors

Affiliations

Conflict of interest statement

References

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