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Review
. 2020 May;35(3):535-543.
doi: 10.3904/kjim.2020.069. Epub 2020 Apr 29.

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

Tae Young Park  1 , Hyoung-Chul Oh  2 , Evan L Fogel  3 , Glen A Lehman  3
Affiliations
Review

Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

Tae Young Park et al. Korean J Intern Med. 2020 May.

Abstract

Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the frequency and severity of this complication. Recently, the use of rectal non-steroidal anti-inflammatory drugs (NSAIDs) have opened a new era for its prevention. This review focuses on the role of NSAIDs in pancreatitis, the pharmacokinetics of these agents, and summarizes the results of clinical trials with rectal NSAIDs alone and combination regimens in the prevention of post-ERCP pancreatitis.

Keywords: Anti-inflammatory agents, non-steroidal; Cholangiopancreatography, endoscopic retrograde; Pancreatitis.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.
Plasma concentration profile of indomethacin in eight human subjects following four different administrations. Adapted from Jensen et al. [31], with permission from John Wiley and Sons. IV, intravenous; IM, intramuscular.
See this image and copyright information in PMC

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