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. 2020 May 7;9(5):352.
doi: 10.3390/pathogens9050352.

Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain

Antoni Soriano-Arandes  1 , Marie Antoinette Frick  1 , Milagros García López-Hortelano  2 , Elena Sulleiro  3 , Carlota Rodó  4 , María Paz Sánchez-Seco  5 , Marta Cabrera-Lafuente  6 , Anna Suy  4 , María De la Calle  7 , Mar Santos  8 , Eugenia Antolin  7 , María Del Carmen Viñuela  9 , María Espiau  1 , Ainara Salazar  1 , Borja Guarch-Ibáñez  10 , Ana Vázquez  5 , Juan Navarro-Morón  11 , José-Tomás Ramos-Amador  12 , Andrea Martin-Nalda  1 , Eva Dueñas  8 , Daniel Blázquez-Gamero  13 , Resurrección Reques-Cosme  14 , Iciar Olabarrieta  15 , Luis Prieto  13 , Fernando De Ory  5 , Claire Thorne  16 , Thomas Byrne  16 , Anthony E Ades  17 , Elisa Ruiz-Burga  16 , Carlo Giaquinto  18 , María José Mellado-Peña  2 , Alfredo García-Alix  19 , Elena Carreras  4 , Pere Soler-Palacín  1
Affiliations

Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain

Antoni Soriano-Arandes et al. Pathogens. .

Abstract

Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children.

Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years.

Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%).

Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.

Keywords: adverse outcome; arboviruses; congenital infection; microcephaly; zika virus.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Flowchart of the study population of the mother–child pair Zika Spanish cohort. *These women were recruited from the total number of screened pregnant women in Spain due to their relationship to where they were being cared for their pregnancy. TOP: termination of pregnancy.
See this image and copyright information in PMC

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