Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2020 May 11;15(1):80.
doi: 10.1186/s13019-020-01125-y.

Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery. A randomized clinical trial

Fatemeh Javaherforooshzadeh  1 , Hasan Abdalbeygi  2 , Farahzad Janatmakan  2 , Behnam Gholizadeh  3
Affiliations
Randomized Controlled Trial

Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery. A randomized clinical trial

Fatemeh Javaherforooshzadeh et al. J Cardiothorac Surg. .

Erratum in

Abstract

Introduction: Pain management after coronary artery bypass graft (CABG) surgery remains challenging.

Objective: This study aimed to compare the effects of Ketorolac and Paracetamol on postoperative CABG pain relief.

Method: This double-blind randomized clinical trial study was conducted in Ahvaz, Iran, from September 2018-December 2019. Two consecutive groups of 60 patients undergoing elective on-pump coronary artery bypass graft surgery.

Intervention: The patients were divided into 0.5 mg/kg of ketorolac mg/dl and 10 mg/kg of Paracetamol after surgery for pain management. Primary outcomes were: visual analog pain scale (VAS) at the time point immediately after extubation (baseline) and at 6, 12, 24 and 48 h and the total dose of morphine consumption. Secondary outcomes included the hemodynamic variables, weaning time, chest tube derange, in-hospital mortality and myocardial infarction.

Statistical analysis: The data were analyzed using SPSS version 22(SPSS, Chicago, IL). The Mann-Whitney U-test was used to compare demographic data, VAS scores, vital signs, and side effects. Repeated measurements were tested within groups using Friedman's ANOVA and the Wilcoxon rank-sum test. Values were expressed as means ± standard deviations. Statistical significance was defined as a p-value < 0.05.

Results: Compared with baseline scores, there were significant declines in VAS scores in both groups throughout the time sequence (P< 0.05). The statistical VAS score was slightly higher in the Paracetamol group at most time points, except for the time of 6 h. However, at 24 and 48 h, the VAS score in group Paracetamol was significantly higher than in group Ketorolac. There were no significant differences between groups about hemodynamic variables.

Conclusion: The efficacy of ketorolac is comparable to that of Paracetamol in postoperative CABG pain relief.

Trial registry: IRCT20150216021098N5. Registered at 2019-09-12.

Keywords: Cardiac surgery; Ketorolac; Paracetamol; Postoperative analgesia; Visual analog score.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflict of interest.

Figures

Fig. 1
Fig. 1
The consort flow chart
Fig. 2
Fig. 2
Postoperative morphine administration
Fig. 3
Fig. 3
VAS score after the operation. There were significant VAS score declines in both groups (P < 0.05)
See this image and copyright information in PMC

References

    1. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003;97(2):534–40. - PubMed
    1. Brennan F, Carr DB, Cousins M. Pain management: a fundamental human right. Anesth Analg. 2007;105(1):205–21. - PubMed
    1. Liu SS, Block BM, Wu CL. Effects of perioperative central neuraxial analgesia on outcome after coronary artery bypass surgery—a meta-analysis. Anesthesiology. 2004;101(1):153–61. - PubMed
    1. Bainbridge D, Martin JE, Cheng DC. Patient-controlledversus nurse-controlled analgesia after cardiac surgery—a meta-analysis. Can J Anesth. 2006;53(5):492. - PubMed
    1. Ucak A, Onan B, Sen H, Selcuk I, Turan A, Yilmaz ATJJ. Anesthesia v: The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2011;25(5):824–9. - PubMed

Publication types

MeSH terms