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. 2020 May 11;30(1):21.
doi: 10.1038/s41533-020-0179-x.

Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies

Ivan S Pradipta  1   2   3 , Daphne Houtsma  4 , Job F M van Boven  5   6 , Jan-Willem C Alffenaar  5   7   8   9 , Eelko Hak  4   6
Affiliations

Interventions to improve medication adherence in tuberculosis patients: a systematic review of randomized controlled studies

Ivan S Pradipta et al. NPJ Prim Care Respir Med. .

Abstract

Non-adherence to anti-tuberculosis (anti-TB) medication is a major risk factor for poor treatment outcomes. We therefore assessed the effectiveness of medication adherence enhancing interventions in TB patients. We report a systematic review of randomized controlled trials that included either latent tuberculosis infection (LTBI) or active TB patients. Outcomes of interest included adherence rate, completed treatment, defaulted treatment and treatment outcomes. We identified four LTBI and ten active TB studies. In active TB patients, directly observed treatment (DOT) by trained community workers, short messaging service combined with education, counselling, monthly TB vouchers, drug box reminders and combinations of those were found effective. In LTBI patients, shorter regimens and DOT effectively improved treatment completion. Interestingly, DOT showed variable effectiveness, highlighting that implementation, population and setting may play important roles. Since non-adherence factors are patient-specific, personalized interventions are required to enhance the impact of a programme to improve medication adherence in TB patients.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Flow diagram of the included articles.
The PRISMA flowchart reporting the number of papers identified, screened, excluded and included.
See this image and copyright information in PMC

References

    1. World Health Organization. Global tuberculosis Report WHO 2018. WHO Report, Vol. 69 (WHO, 2018).
    1. World Health Organization. Guidelines for Treatment of Drug-Susceptible Tuberculosis and Patient Care 2017 Update (World health Organization, 2017).
    1. Jasmer RM, Nahid P, Hopewell PC. Clinical practice latent tuberculosis infection. N. Engl. J. Med. 2002;347:1860–1866. doi: 10.1056/NEJMcp021045. - DOI - PubMed
    1. World Health Organization (WHO). Consolidated Guidelines on Drug-Resistant Tuberculosis Treatment (World health Organization, 2019). - PubMed
    1. Munro SA, et al. Patient adherence to tuberculosis treatment: a systematic review of qualitative research. PLoS Med. 2007;4:1230–1245. doi: 10.1371/journal.pmed.0040238. - DOI - PMC - PubMed

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