Selective stabilization supports phosphatase targeting in cancer

Comment

Joseph Willson. Nat Rev Drug Discov. 2020 Jun.

. 2020 Jun;19(6):387.

doi: 10.1038/d41573-020-00091-3.

No abstract available

Comment on

Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
Leonard D, Huang W, Izadmehr S, O'Connor CM, Wiredja DD, Wang Z, Zaware N, Chen Y, Schlatzer DM, Kiselar J, Vasireddi N, Schüchner S, Perl AL, Galsky MD, Xu W, Brautigan DL, Ogris E, Taylor DJ, Narla G. Leonard D, et al. Cell. 2020 Apr 30;181(3):688-701.e16. doi: 10.1016/j.cell.2020.03.038. Epub 2020 Apr 20. Cell. 2020. PMID: 32315618 Free PMC article.
Retracted: Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2.
Morita K, He S, Nowak RP, Wang J, Zimmerman MW, Fu C, Durbin AD, Martel MW, Prutsch N, Gray NS, Fischer ES, Look AT. Morita K, et al. Cell. 2020 Apr 30;181(3):702-715.e20. doi: 10.1016/j.cell.2020.03.051. Epub 2020 Apr 20. Cell. 2020. Retraction in: Cell. 2022 Aug 4;185(16):3058. doi: 10.1016/j.cell.2022.07.008. PMID: 32315619 Free PMC article. Retracted.

1. Leonard, D. et al. Selective PP2A enhancement through biased heterotrimer stabilization. Cell 181, 688–701 (2020) - PubMed - DOI
1. Morita, K. et al. Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2. Cell 181, 702–715 (2020) - PubMed - DOI - PMC