Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr;12(4):1681-1694.
doi: 10.21037/jtd.2019.12.130.

Current developments in endovascular therapy of peripheral vascular disease

Damianos G Kokkinidis  1 , Ehrin J Armstrong  1
Affiliations
Review

Current developments in endovascular therapy of peripheral vascular disease

Damianos G Kokkinidis et al. J Thorac Dis. 2020 Apr.

Abstract

More than 200 million people worldwide have peripheral artery disease (PAD) or its most severe manifestation, critical limb ischemia (CLI). While endovascular treatment has become first line therapy in most cases, a number of challenges remain for optimal treatment of femoropopliteal (FP) or infrapopliteal (IP) disease, especially when these lesions are severely calcified, chronic total occlusions (CTOs) or in-stent restenosis (ISR). Continued evolution of technologies has significantly improved the outcomes for endovascular treatment. A number of new devices are in the pipeline right now, including new paclitaxel eluting stents and balloons, intravascular lithotripsy to treat severely calcified lesions, adventitial delivery of anti-restenotic agents to limit restenosis rates, and percutaneous femoro-popliteal bypass.

Keywords: adventitial delivery; below the knee arteries; chronic total occlusions (CTOs); drug-coated balloons (DCBs); drug-eluting stents (DES); emerging therapies; femoropopliteal disease; infrapopliteal disease; lithotripsy; novel technologies; percutaneous bypass; peripheral artery disease.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd.2019.12.130). The series “Interventional Cardiology” was commissioned by the editorial office without any funding or sponsorship. EJA is a consultant to Abbott Vascular, Boston Scientific, Cardiovascular Systems, Gore, Intact Vascular, Janssen, Medtronic, and Philips. DGK has no other conflicts of interest to declare.

References

    1. Shu J, Santulli G. Update on peripheral artery disease: epidemiology and evidence-based facts. Atherosclerosis 2018;275:379-81. 10.1016/j.atherosclerosis.2018.05.033 - DOI - PMC - PubMed
    1. Kokkinidis DG, Armstrong EJ. Emerging and Future Therapeutic Options for Femoropopliteal and Infrapopliteal Endovascular Intervention. Interv Cardiol Clin 2017;6:279-95. 10.1016/j.iccl.2016.12.011 - DOI - PubMed
    1. Varu VN, Hogg ME, Kibbe MR. Critical limb ischemia. J Vasc Surg 2010;51:230-41. 10.1016/j.jvs.2009.08.073 - DOI - PubMed
    1. Novo S, Coppola G, Milio G. Critical limb ischemia: definition and natural history. Curr Drug Targets Cardiovasc Haematol Disord 2004;4:219-25. 10.2174/1568006043335989 - DOI - PubMed
    1. Olin JW, Allie DE, Belkin M, et al. ACCF/AHA/ACR/SCAI/SIR/SVM/SVN/SVS 2010 Performance Measures for Adults With Peripheral Artery Disease: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures, the American College of Radiology, the Society for Cardiac Angiography and Interventions, the Society for Interventional Radiology, the Society for Vascular Medicine, the Society for Vascular Nursing, and the Society for Vascular Surgery (Writing Committee to Develop Clinical Performance Measures for Peripheral Artery Disease) Developed in Collaboration With the American Association of Cardiovascular and Pulmonary Rehabilitation; the American Diabetes Association; the Society for Atherosclerosis Imaging and Prevention; the Society for Cardiovascular Magnetic Resonance; the Society of Cardiovascular Computed Tomography; and the PAD Coalition Endorsed by the American Academy of Podiatric Practice Management. J Am Coll Cardiol 2010;56:2147-81. 10.1016/j.jacc.2010.08.606 - DOI - PubMed