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Case Reports
. 2021 Mar:31:2-5.
doi: 10.1016/j.mmcr.2020.05.001. Epub 2020 May 11.

Invasive pulmonary aspergillosis complicating COVID-19 in the ICU - A case report

Juergen Prattes  1 , Thomas Valentin  1 , Martin Hoenigl  1   2 , Emina Talakic  3 , Alexander C Reisinger  4 , Philipp Eller  4
Affiliations
Case Reports

Invasive pulmonary aspergillosis complicating COVID-19 in the ICU - A case report

Juergen Prattes et al. Med Mycol Case Rep. 2021 Mar.

Abstract

It is not yet known, if critically ill COVID-19 patients are prone to fungal infections. We report a 69-year-old patient without typical risk factors for invasive pulmonary aspergillosis (IPA), who developed IPA two weeks after onset of symptoms. Our report shows that IPA may occur in critically ill COVID-19 patients.

Keywords: Aspergillosis; COVID-19; ICU.

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Conflict of interest statement

All authors declare that they have no conflicts of interest regarding this manuscript.

Figures

Fig. 1
Fig. 1
Timeline representing the course of COVID-19 in the reported patient Abbreviations: q.d. = once daily; b.i.d. = twice daily, i.v. = intravenous; LFD = lateral-flow device; ER = emergency room; ARDS = acute respiratory distress syndrome; ICU = intensive care unit; SARS-CoV-2 = Severe acute respiratory syndrome coronavirus 2, CT = computed tomography * Voriconazole dosage: 6 mg/kg twice daily on day 1, followed by 4 mg/kg twice daily. Chest imagings displayed here are also displayed in more detail in Fig. 2.
Fig. 2
Fig. 2
Fig. 2a and b representing findings on chest X-ray performed on day 6 of symptom onset. The lateral chest view revealed bilateral dorsal and basal coarse reticular opacities, no pleural effusions. Fig. 2c and d representing chest CT scans on day 12 of symptom onset. Axial CT image of the chest demonstrate extensive-ground glass opacities with bilateral and multi-lobar distribution (2c) and a combination of consolidation and surrounding ground-glass opacities basal in the posterior left lower lung (“reversed halo sign” - shown by the arrow) (2d).
See this image and copyright information in PMC

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