Potential of combination therapy in EGFR mutated lung cancer
- PMID: 32395562
- PMCID: PMC7210119
- DOI: 10.21037/atm.2020.03.76
Potential of combination therapy in EGFR mutated lung cancer
Conflict of interest statement
Conflicts of Interest: The author has completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm.2020.03.76). The author received lecture fees from Chugai Pharmaceutical., AstraZeneca, and Boehringer and has been supported through clinical studies by Chugai Pharmaceutical.
Comment on
-
Erlotinib plus bevacizumab for EGFR-mutant advanced non-squamous non-small-cell lung cancer patients: ready for first-line?Ann Transl Med. 2019 Dec;7(Suppl 8):S346. doi: 10.21037/atm.2019.09.116. Ann Transl Med. 2019. PMID: 32016064 Free PMC article. No abstract available.
Similar articles
-
Heterogeneous resistance mechanisms in an EGFR exon 19-mutated non-small cell lung cancer patient treated with erlotinib: Persistent FGFR3-mutation, localized transformation to EGFR-mutated SCLC, and acquired T790M EGFR-mutation.Lung Cancer. 2017 Nov;113:14-17. doi: 10.1016/j.lungcan.2017.08.024. Epub 2017 Sep 1. Lung Cancer. 2017. PMID: 29110841
-
Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer.Elife. 2020 Sep 8;9:e58204. doi: 10.7554/eLife.58204. Elife. 2020. PMID: 32897190 Free PMC article.
-
[Effects of anti-PD-L1 monoclonal antibody and EGFR-TKI on the expression of PD-L1 and function of T lymphocytes in EGFR-mutated lung cancer cells].Zhonghua Zhong Liu Za Zhi. 2016 Dec 23;38(12):886-892. doi: 10.3760/cma.j.issn.0253-3766.2016.12.002. Zhonghua Zhong Liu Za Zhi. 2016. PMID: 27998463 Chinese.
-
Tumor immune microenvironment in epidermal growth factor receptor-mutated non-small cell lung cancer before and after epidermal growth factor receptor tyrosine kinase inhibitor treatment: a narrative review.Transl Lung Cancer Res. 2021 Sep;10(9):3823-3839. doi: 10.21037/tlcr-21-572. Transl Lung Cancer Res. 2021. PMID: 34733631 Free PMC article. Review.
-
Combined Inhibition of EGFR and VEGF Pathways in Patients with EGFR-Mutated Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.Curr Oncol Rep. 2020 Sep 18;22(12):119. doi: 10.1007/s11912-020-00981-0. Curr Oncol Rep. 2020. PMID: 32945977
Cited by
-
A retrospective study of the efficacy of combined EGFR‑TKI plus VEGF inhibitor/cytotoxic therapy vs. EGFR‑TKI monotherapy for PD‑L1‑positive EGFR‑mutant non‑small cell lung cancer: North Japan Lung Cancer Study Group 2202.Oncol Lett. 2023 Jun 20;26(2):334. doi: 10.3892/ol.2023.13920. eCollection 2023 Aug. Oncol Lett. 2023. PMID: 37427337 Free PMC article.
References
-
- Saito H, Fukuhara T, Furuya N, et al. Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial. Lancet Oncol 2019;20:625-35. 10.1016/S1470-2045(19)30035-X - DOI - PubMed
-
- Seto T, Kato T, Nishio M, et al. Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an openlabel, randomised, multicentre, phase 2 study. Lancet Oncol 2014;15:1236-44. 10.1016/S1470-2045(14)70381-X - DOI - PubMed
Publication types
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous