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Review
. 2020 Jul;67(4):1485-1491.
doi: 10.1111/tbed.13620. Epub 2020 May 31.

Recent progress on the diagnosis of 2019 Novel Coronavirus

Chun Li  1 , Linzhu Ren  2
Affiliations
Review

Recent progress on the diagnosis of 2019 Novel Coronavirus

Chun Li et al. Transbound Emerg Dis. 2020 Jul.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Transbound Emerg Dis. 2020 Nov;67(6):3076. doi: 10.1111/tbed.13838. Transbound Emerg Dis. 2020. PMID: 33300309 Free PMC article. No abstract available.

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Therefore, convenient, timely and accurate detection of SARS-CoV-2 is urgently needed. Here, we review the types, characteristics and shortcomings of various detection methods, as well as perspectives for the SARS-CoV-2 diagnosis. Clinically, nucleic acid-based methods are sensitive but prone to false-positive. The antibody-based method has slightly lower sensitivity but higher accuracy. Therefore, it is suggested to combine the two methods to improve the detection accuracy of COVID-19.

Keywords: Corona Virus Disease 2019 (COVID-19); antibody; clustered regularly interspaced short palindromic repeats (CRISPR); detection; real-time RT-PCR; reverse transcription loop-mediated isothermal amplification (RT-LAMP); severe acute respiratory syndrome coronavirus 2 (2019 Novel Coronavirus SARS-CoV-2).

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Conflict of interest statement

The authors declare no conflict of interest.

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