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. 2020 Jun 18;56(48):6547-6550.
doi: 10.1039/d0cc02053b. Epub 2020 May 12.

Telomeric DNA-RNA-hybrid G-quadruplex exists in environmental conditions of HeLa cells

Hong-Liang Bao  1 , Yan Xu
Affiliations

Telomeric DNA-RNA-hybrid G-quadruplex exists in environmental conditions of HeLa cells

Hong-Liang Bao et al. Chem Commun (Camb). .

Abstract

In the present study, we employed a 19F NMR approach to study the association of telomere RNA and DNA in vitro and in living human cells. We successfully characterized the DNA-RNA hybrid G-quadruplex (HQ) structure formed by telomeric DNA and RNA. We further demonstrated for the first time that an HQ conformation can exist in the environmental conditions of HeLa cells.

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