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Comparative Study
. 2020 May 12;323(18):1852-1854.
doi: 10.1001/jama.2020.2047.

Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017

Sarah H Cross  1 , Mandeep R Mehra  2 , Deepak L Bhatt  2 , Khurram Nasir  3 , Christopher J O'Donnell  4 , Robert M Califf  5 , Haider J Warraich  4
Affiliations
Comparative Study

Rural-Urban Differences in Cardiovascular Mortality in the US, 1999-2017

Sarah H Cross et al. JAMA. .

Abstract

This study used data from the US Centers for Disease Control and Prevention WONDER database to examined temporal trends in cardiovascular disease age-adjusted mortality rates overall and across subgroups stratified by rural-urban area designation in the US.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Mehra reported receiving travel support and consulting fees, paid to Brigham and Women’s Hospital, from Abbott; fees for serving on a steering committee from Medtronic and Janssen (Johnson & Johnson); fees for serving on a data and safety monitoring board from Mesoblast; consulting fees from Portola, Bayer, and Triple Gene; and fees for serving as a scientific board member from NuPulseCV, Leviticus, and FineHeart. Dr Bhatt disclosed the following relationships—advisory board: Cardax, Cereno Scientific, Elsevier Practice Update Cardiology, Medscape Cardiology, PhaseBio, and Regado Biosciences; board of directors: Boston VA Research Institute, Society of Cardiovascular Patient Care, and TobeSoft; chair: American Heart Association Quality Oversight Committee; data monitoring committees: Baim Institute for Clinical Research, Cleveland Clinic, Duke Clinical Research Institute, Mayo Clinic, Mount Sinai School of Medicine, and Population Health Research Institute; honoraria: American College of Cardiology, Baim Institute for Clinical Research, Belvoir Publications, Duke Clinical Research Institute, HMP Global, Journal of the American College of Cardiology, Medtelligence/ReachMD, Population Health Research Institute, Slack Publications, Society of Cardiovascular Patient Care, and WebMD; other: Clinical Cardiology, NCDR-ACTION Registry Steering Committee, VA CART Research and Publications Committee; research funding: Abbott, Afimmune, Amarin, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Chiesi, CSL Behring, Eisai, Ethicon, Ferring Pharmaceuticals, Forest Laboratories, Fractyl, Idorsia, Ironwood, Ischemix, Lilly, Medtronic, PhaseBio, Pfizer, PLx Pharma, Regeneron, Roche, Sanofi Aventis, Synaptic, and the Medicines Company; royalties: Elsevier; site co-investigator: Biotronik, Boston Scientific, St Jude Medical, and Svelte; trustee: American College of Cardiology; and unfunded research: FlowCo, Merck, Novo Nordisk, and Takeda. Dr Nasir reported being supported by the Jerold B. Katz Academy of Translational Research. Dr Califf reported serving on the corporate board for Cytokinetics; being the board chair for the People-Centered Research Foundation; and receiving personal fees for consulting from Merck, Amgen, AstraZeneca, Biogen, Genentech, Eli Lilly, and Boehringer Ingelheim; and receiving other funding from Verily Life Sciences and Google Health. No other disclosures were reported.

References

    1. Roth GA, Dwyer-Lindgren L, Bertozzi-Villa A, et al. . Trends and patterns of geographic variation in cardiovascular mortality among US counties, 1980-2014. JAMA. 2017;317(19):1976-1992. doi:10.1001/jama.2017.4150 - DOI - PMC - PubMed
    1. Garcia MC, Rossen LM, Bastian B, et al. . Potentially excess deaths from the five leading causes of death in metropolitan and nonmetropolitan counties—United States, 2010-2017. MMWR Surveill Summ. 2019;68(10):1-11. doi:10.15585/mmwr.ss6810a1 - DOI - PubMed
    1. US Centers for Disease Control and Prevention CDC WONDER. Accessed January 5, 2020. https://wonder.cdc.gov
    1. Sidney S, Quesenberry CP, Jaffe MG, et al. . Recent trends in cardiovascular mortality in the United States and public health goals. JAMA Cardiol. 2016;1(5):594-599. - PubMed
    1. Ingram DD, Franco SJ. 2013 NCHS urban-rural classification scheme for counties. Vital Health Stat 2. 2014;(166):1-73. - PubMed

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