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. 2020 Sep;17(9):1161-1163.
doi: 10.1513/AnnalsATS.202004-376RL.

Subphenotyping Acute Respiratory Distress Syndrome in Patients with COVID-19: Consequences for Ventilator Management

Lieuwe D J Bos  1   2 , Frederique Paulus  1 , Alexander P J Vlaar  1 , Ludo F M Beenen  1 , Marcus J Schultz  1   3   4
Affiliations

Subphenotyping Acute Respiratory Distress Syndrome in Patients with COVID-19: Consequences for Ventilator Management

Lieuwe D J Bos et al. Ann Am Thorac Soc. 2020 Sep.
No abstract available

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Figures

Figure 1.
Figure 1.
Association between compliance of the respiratory system (Crs) and percentage of affected lung parenchyma. x-axis: Crs; y-axis: percentage of lung that is poorly aerated or nonaerated, expressed semiquantitatively as quartiles. The boxplots indicate the distribution of the variables on the x- and y-axes. The red area and solid red symbols indicate patients with a consistent H-phenotype. The blue area and solid blue symbols indicate patients with a consistent L-phenotype. The solid gray symbols correspond to patients with a discordant phenotype. Indicative computed tomography images for each area are shown on both sides. Crs is not associated with an increase in poorly aerated/nonaerated lung tissue estimated by semiquantitative analysis in quartiles. Regression coefficient for Crs: +0.13% per ml/cm H2O (95% confidence interval, −0.17 to +0.42; P = 0.39). Two patients met the criteria for the L-phenotype and 12 patients met the criteria for the H-phenotype, leaving 24 patients (63%) with discordant results and an unclear phenotype allocation. Most patients had a nonfocal lung morphology (n = 30, 79%) rather than a focal lung morphology (n = 8, 21%). ARDS = acute respiratory distress syndrome; COVID-19 = coronavirus disease.
See this image and copyright information in PMC

References

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