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Comment
. 2020 May 11;37(5):619-621.
doi: 10.1016/j.ccell.2020.04.011.

Bridging the Gap: The Impact of Genetic Ancestry on Routes to Tumorigenesis

Chaitanya Bandlamudi  1 , Barry S Taylor  2
Affiliations
Free article
Comment

Bridging the Gap: The Impact of Genetic Ancestry on Routes to Tumorigenesis

Chaitanya Bandlamudi et al. Cancer Cell. .
Free article

Abstract

Whether ancestry drives molecular differences that underlie disparities in cancer incidence and outcome is poorly understood. In this issue of Cancer Cell, Carrot-Zhang et al., through a rigorous analytical framework, explore ancestry-specific patterns of molecular alterations in cancers and demonstrate the need for novel strategies to address this formidable challenge.

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Conflict of interest statement

Declaration of Interests B.S.T. reports receiving honoria and research funding from Genentech and Illumina and advisory board activities for Boehringer Ingelheim and Loxo Oncology, a wholly owned subsidiary of Eli Lilly, Inc. All stated activities were outside of the work described herein.

Comment on

  • Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.
    Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E; Cancer Genome Atlas Analysis Network; Cherniack AD, Beroukhim R. Carrot-Zhang J, et al. Cancer Cell. 2020 May 11;37(5):639-654.e6. doi: 10.1016/j.ccell.2020.04.012. Cancer Cell. 2020. PMID: 32396860 Free PMC article.

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