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Comment
. 2020 May 11;37(5):623-624.
doi: 10.1016/j.ccell.2020.04.007.

Expanding the Role for Immunotherapy in Triple-Negative Breast Cancer

Peter Savas  1 , Sherene Loi  2
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Expanding the Role for Immunotherapy in Triple-Negative Breast Cancer

Peter Savas et al. Cancer Cell. .
Free article

Abstract

PD-1 axis blockade, in combination with chemotherapy, improves outcomes in advanced triple-negative breast cancer that is PD-L1 positive. The phase 3 KEYNOTE-522 trial now shows that the addition of pembrolizumab to chemotherapy improves pathological complete response rates regardless of PD-L1 status and appears to improve survival.

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Conflict of interest statement

Declaration of Interests P.S. has served as an uncompensated consultant to Roche-Genentech. S.L. receives research funding to her institution from Novartis, Bristol Meyers Squibb, Merck, Roche-Genentech, Puma Biotechnology, Pfizer, Eli Lilly, and Seattle Genetics. She has acted as consultant (not compensated) to Seattle Genetics, Pfizer, Novartis, BMS, Merck, AstraZeneca, and Roche-Genentech. She has acted as consultant (paid to her institution) to Aduro Biotech, Novartis, and G1 Therapeutics.

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