Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May 9;9(5):1407.
doi: 10.3390/jcm9051407.

Impact of COVID-19 on the Cardiovascular System: A Review

Affiliations
Review

Impact of COVID-19 on the Cardiovascular System: A Review

Kensuke Matsushita et al. J Clin Med. .

Abstract

The recent outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has been declared a public health emergency of international concern. COVID-19 may present as acute respiratory distress syndrome in severe cases, and patients with pre-existing cardiovascular comorbidities are reported to be the most vulnerable. Notably, acute myocardial injury, determined by elevated high-sensitivity troponin levels, is commonly observed in severe cases, and is strongly associated with mortality. Therefore, understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for critically ill patients. In this review, we summarize the rapidly evolving data and highlight the cardiovascular considerations related to COVID-19.

Keywords: COVID-19; cardiovascular disease; myocardial injury.

PubMed Disclaimer

Conflict of interest statement

Matsushita has received scholarship from Groupe pour l’Enseignement, la prévention et la Recherche Cardiologique en Alsace. Other authors have reported that they have no relationship to disclose.

Figures

Figure 1
Figure 1
Potential Mechanisms of Cardiovascular Complication Caused by COVID-19. ARDS, acute respiratory distress syndrome; COVID-19, coronavirus disease 2019; CV, cardiovascular. Images were adapted from smart.servier.com by Kensuke Matsushita, 2020, https://creativecommons.org/licenses/by/3.0/ [51].

References

    1. Chan J.F., Yuan S., Kok K.H., To K.K., Chu H., Yang J., Xing F., Liu J., Yip C.C., Poon R.W., et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet (Lond. Engl.) 2020;395:514–523. doi: 10.1016/S0140-6736(20)30154-9. - DOI - PMC - PubMed
    1. Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect. Dis. 2020;20:533–534. doi: 10.1016/S1473-3099(20)30120-1. - DOI - PMC - PubMed
    1. Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y., et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet (Lond. Engl.) 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. - DOI - PMC - PubMed
    1. Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. - DOI - PMC - PubMed
    1. Biondi-Zoccai G., Landoni G., Carnevale R., Cavarretta E., Sciarretta S., Frati G. SARS-CoV-2 and COVID-19: Facing the pandemic together as citizens and cardiovascular practitioners. Minerva Cardioangiol. 2020 doi: 10.23736/s0026-4725.20.05250-0. - DOI - PubMed

LinkOut - more resources