. 2020 Aug 27;56(2):2001526.

doi: 10.1183/13993003.01526-2020. Print 2020 Aug.

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Hai-Qiong Yu^{1

2}, Bao-Qing Sun^{3

2}, Zhang-Fu Fang^{1

3

4

2}, Jin-Cun Zhao^{3

2}, Xiao-Yu Liu^{1

2}, Yi-Min Li^{3

2}, Xi-Zhuo Sun^{4

2}, Hong-Feng Liang^{5

2}, Bei Zhong^{6

2}, Zhi-Feng Huang^{3

2}, Pei-Yan Zheng³, Li-Feng Tian⁷, Hui-Qi Qu⁷, De-Chen Liu⁸, Er-Yi Wang^{1

4}, Xiao-Jun Xiao¹, Shi-Yue Li³, Feng Ye³, Li Guan⁴, Dong-Sheng Hu⁸, Hakon Hakonarson^{7

9

10}, Zhi-Gang Liu^{1

10}, Nan-Shan Zhong^{11

10}

Affiliations

¹ State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China.
² These authors contributed equally to this work.
³ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁴ Dept of Respirology and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
⁵ Yangjiang People's Hospital, Yangjiang, China.
⁶ Dept of Infectious Disease, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
⁷ Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁸ Dept of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, China.
⁹ Divisions of Human Genetics and Pulmonary Medicine, Dept of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Hakon Hakonarson, Zhi-gang Liu and Nan-shan Zhong are joint lead authors.
¹¹ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China nanshan@vip.163.com.

PMID: 32398307
PMCID: PMC7236821
DOI: 10.1183/13993003.01526-2020

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Hai-Qiong Yu et al. Eur Respir J. 2020.

. 2020 Aug 27;56(2):2001526.

doi: 10.1183/13993003.01526-2020. Print 2020 Aug.

Authors

Affiliations

¹ State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy and Immunology, Shenzhen University School of Medicine, Shenzhen, China.
² These authors contributed equally to this work.
³ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁴ Dept of Respirology and Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen, China.
⁵ Yangjiang People's Hospital, Yangjiang, China.
⁶ Dept of Infectious Disease, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China.
⁷ Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
⁸ Dept of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, China.
⁹ Divisions of Human Genetics and Pulmonary Medicine, Dept of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
¹⁰ Hakon Hakonarson, Zhi-gang Liu and Nan-shan Zhong are joint lead authors.
¹¹ State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China nanshan@vip.163.com.

PMID: 32398307
PMCID: PMC7236821
DOI: 10.1183/13993003.01526-2020

Abstract

Humoral immune response to SARS-CoV-2 showed an early response of IgA, instead of IgM, in COVID-19 patients. As highlighted by this study, enhanced IgA responses observed in severe COVID-19 might confer damaging effects in severe COVID-19. https://bit.ly/3fA7c1I

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Conflict of interest statement

Conflict of interest: Hai-qiong Yu has nothing to disclose. Conflict of interest: Bao-qing Sun has nothing to disclose. Conflict of interest: Zhang-fu Fang has nothing to disclose. Conflict of interest: Jin-cun Zhao has nothing to disclose. Conflict of interest: Xiao-yu Liu has nothing to disclose. Conflict of interest: Yi-min Li has nothing to disclose. Conflict of interest: Xi-zhuo Sun has nothing to disclose. Conflict of interest: Hong-feng Liang has nothing to disclose. Conflict of interest: Bei Zhong has nothing to disclose. Conflict of interest: Zhi-feng Huang has nothing to disclose. Conflict of interest: Pei-yan Zheng has nothing to disclose. Conflict of interest: Li-feng Tian has nothing to disclose. Conflict of interest: Hui-Qi Qu has nothing to disclose. Conflict of interest: De-chen Liu has nothing to disclose. Conflict of interest: Er-yi Wang has nothing to disclose. Conflict of interest: Xiao-jun Xiao has nothing to disclose. Conflict of interest: Shi-yue Li has nothing to disclose. Conflict of interest: Feng Ye has nothing to disclose. Conflict of interest: Li Guan has nothing to disclose. Conflict of interest: Dong-sheng Hu has nothing to disclose. Conflict of interest: Hakon Hakonarson has nothing to disclose. Conflict of interest: Zhi-gang Liu has nothing to disclose. Conflict of interest: Nan-shan Zhong has nothing to disclose.

Figures

**FIGURE 1**
Chronological profiles of antibodies in patients with coronavirus disease 2019. Samples collected since illness onset and during weeks 0–1, 1–2, 2–3, 3–4, 4–5, 5–6, 6–7 and 7–8 were pooled for analysis. a and b) The medians of the antibody detection values (luminescent values) of samples at the same time-point since onset in a) all patients and b) patients with severe illness. c–e) Time-serial changes of the levels of different antibodies in severe and nonsevere groups. The medians of antibody detection values (luminescent values) of samples at the same time-point since onset for c) IgA, d) IgG and e) IgM.

See this image and copyright information in PMC

References

1. Sanche S, Lin YT, Xu C, et al. . High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. Emerging Infect Dis 2020; 26: 1470–1477. - PMC - PubMed
1. Wang C, Horby PW, Hayden FG, et al. . A novel coronavirus outbreak of global health concern. Lancet 2020; 395: 470–473. doi:10.1016/S0140-6736(20)30185-9 - DOI - PMC - PubMed
1. Liu L, Wei Q, Lin Q, et al. . Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. JCI Insight 2019; 4: 123158. doi:10.1172/jci.insight.123158 - DOI - PMC - PubMed
1. Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 7) http://www.gov.cn/zhengce/zhengceku/2020-03/04/content_5486705.htm Date last accessed: 4 May 2020. Date last updated: 3 March 2020.
1. Hsueh P-R, Huang L-M, Chen P-J, et al. . Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus. Clin Microbiol Infect 2004; 10: 1062–1066. doi:10.1111/j.1469-0691.2004.01009.x - DOI - PMC - PubMed

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Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Affiliations

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Research Materials

Miscellaneous