Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?
- PMID: 32398309
- PMCID: PMC7236827
- DOI: 10.1183/13993003.01560-2020
Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?
Abstract
Exogenous supplement of recombinant human (rh)ACE-2 might be a brilliant idea in the treatment of COVID-19. Soluble ACE-2 might impact viral spread, since binding to soluble receptor has been shown to block SARS-CoV-2 entry.
Conflict of interest statement
Conflict of interest: D. Lutchman has nothing to disclose.
Comment in
-
Smoking, ACE-2 and COVID-19: ongoing controversies.Eur Respir J. 2020 Jul 16;56(1):2001759. doi: 10.1183/13993003.01759-2020. Print 2020 Jul. Eur Respir J. 2020. PMID: 32430431 Free PMC article.
Comment on
-
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19.Eur Respir J. 2020 May 14;55(5):2000688. doi: 10.1183/13993003.00688-2020. Print 2020 May. Eur Respir J. 2020. PMID: 32269089 Free PMC article.
-
COVID-19 and smoking: is nicotine the hidden link?Eur Respir J. 2020 Jun 4;55(6):2001116. doi: 10.1183/13993003.01116-2020. Print 2020 Jun. Eur Respir J. 2020. PMID: 32341101 Free PMC article.
-
COVID-19 and nicotine as a mediator of ACE-2.Eur Respir J. 2020 Jun 4;55(6):2001261. doi: 10.1183/13993003.01261-2020. Print 2020 Jun. Eur Respir J. 2020. PMID: 32350104 Free PMC article.
References
-
- Olds JL, Kabbani N. Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? FEBS J 2020; in press [https://doi.org/10.1111/febs.15303]. doi:10.1111/febs.15303 - DOI - PMC - PubMed
-
- Changeux JP, Amoura Z, Rey F, et al. . A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. Qeios 2020; preprint [https://doi.org/10.32388/FXGQSB]. doi:10.32388/FXGQSB - DOI - PubMed
-
- Berlin I, Thomas D, Le Faou AL, et al. . COVID-19 and smoking. Nicotine Tob Res 2020; in press [https://doi.org/10.1093/ntr/ntaa059]. doi:10.1093/ntr/ntaa059 - DOI - PMC - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous