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. 2020 Jun;26(6):842-844.
doi: 10.1038/s41591-020-0901-9. Epub 2020 May 12.

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao #  1 , Yang Liu #  1 , Jing Yuan #  2 , Yanling Wen  1 , Gang Xu  1 , Juanjuan Zhao  1 , Lin Cheng  1 , Jinxiu Li  2 , Xin Wang  1 , Fuxiang Wang  2 , Lei Liu  3   4 , Ido Amit  5 , Shuye Zhang  6 , Zheng Zhang  7   8
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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al. Nat Med. 2020 Jun.

Abstract

Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.

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References

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