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. 1988 Oct;24(4):574-6.
doi: 10.1002/ana.410240415.

Rate of cell death in parkinsonism indicates active neuropathological process

P L McGeer  1 , S Itagaki, H Akiyama, E G McGeer
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Rate of cell death in parkinsonism indicates active neuropathological process

P L McGeer et al. Ann Neurol. 1988 Oct.

Abstract

It has been hypothesized that idiopathic parkinsonism might be due to age-related attrition of dopamine neurons occurring long after an initial acute episode. We present evidence against this hypothesis, based on our finding of at least six times as many HLA-DR-positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control brains. This difference indicates an active pathological process.

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