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. 2021 Mar;36(2):325-337.
doi: 10.1007/s10103-020-03033-y. Epub 2020 May 12.

Laser enhancement of cancer cell destruction by photothermal therapy conjugated glutathione (GSH)-coated small-sized gold nanoparticles

Lamyaa F A Al-Barram  1
Affiliations

Laser enhancement of cancer cell destruction by photothermal therapy conjugated glutathione (GSH)-coated small-sized gold nanoparticles

Lamyaa F A Al-Barram. Lasers Med Sci. 2021 Mar.

Abstract

The current study presents the employment of glutathione (GSH)-modified small-sized gold nanoparticles (AuNPs) ~ 3 nm in photothermal therapy (PTT), to evaluate the targeting and the toxic effect of cancer rather than normal cells. GSH is pH-sensitive surfaces that exhibit a fast response to the variation in pH conditions between normal (~ 7.4) and cancer cells (6-6.5). Results showed a considerable toxic impact via GSH-AuNP accumulation in cancer cells by both green and NIR laser irradiation. A proportional relation of cellular death to AuNP concentration, exposure time, and light-to-heat conversion efficiency has been demonstrated. The small-sized GSH-AuNPs represent promising agents for developing the safety issues of photothermal cancer treatment by the selective targeting of cancer rather than normal cells, reducing the NP toxicity by their size overlapping with the renal clearance barrier of kidney filtration (~ 5.5 nm), and promoting the photothermal performance in the NIR region, in which light penetration into deep cancer regions is more interested.

Keywords: GSH; Laser; Photothermal therapy; Small-sized gold nanoparticles.

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