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Review
. 2020 Jul;103(1_Suppl):114-124.
doi: 10.4269/ajtmh.19-0786.

The Schistosomiasis Consortium for Operational Research and Evaluation 2008-2020: Approaches, Experiences, Lessons, and Recommendations

Sue Binder  1 , Carl H Campbell  1 , Tamara S Andros  1 , Jennifer D Castleman  1 , Nupur Kittur  1 , Charles H King  1   2 , Daniel G Colley  1   3
Affiliations
Review

The Schistosomiasis Consortium for Operational Research and Evaluation 2008-2020: Approaches, Experiences, Lessons, and Recommendations

Sue Binder et al. Am J Trop Med Hyg. 2020 Jul.

Abstract

For the past 10 years, the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), funded by the Bill & Melinda Gates Foundation, has been supporting operational research to provide a stronger evidence base for controlling and moving toward elimination of schistosomiasis. The SCORE portfolio was developed and implemented with engagement from many stakeholders and sectors. Particular efforts were made to include endemic country neglected tropical disease program managers. Examples of the challenges we encountered include the need to balance rigor (e.g., conducting large cluster-randomized trials) with ensuring relevance to real-world settings, allowing for local contexts while standardizing key study aspects, adjusting to evolving technologies, and incorporating changing technologies into multiyear studies. The Schistosomiasis Consortium for Operational Research and Evaluation's findings and data and the collected specimens will continue to be useful in the years to come. Our experiences and lessons learned can benefit both program managers and researchers conducting similar work in the future.

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Conflict of interest statement

Disclosure: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Colley DG, Jacobson JA, Binder S, 2020. Schistosomiasis Consortium for Operational Research and Evaluation (SCORE): its foundations, development, and evolution. Am J Trop Med Hyg 103 (Suppl 1): 5–13. - PMC - PubMed
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    1. Kittur N, et al. 2020. Discovering, defining, and summarizing persistent hotspots in SCORE studies. Am J Trop Med Hyg 103 (Suppl 1): 24–29. - PMC - PubMed
    1. Colley DG, et al. 2020. Evaluation, validation, and recognition of the point-of-care circulating cathodic antigen, urine-based assay for mapping Schistosoma mansoni infections. Am J Trop Med Hyg 103 (Suppl 1): 42–49. - PMC - PubMed
    1. Corstjens PLAM, et al. 2020. Circulating Anodic Antigen (CAA): a highly sensitive diagnostic biomarker to detect active Schistosoma infections–improvements and use during SCORE. Am J Trop Med Hyg 103 (Suppl 1): 50–57. - PMC - PubMed

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