Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 May 13:9:e58084.
doi: 10.7554/eLife.58084.

A role for fat precursors in the marrow

Noriaki Ono  1
Affiliations
Comment

A role for fat precursors in the marrow

Noriaki Ono. Elife. .

Abstract

A group of cells that can become adipocytes controls the formation of blood vessels in the bone marrow, and also regulates the differentiation of resident mesenchymal progenitor cells.

Keywords: adipocyte; blood vessel; bone marrow mesenchymal stem cells; cell biology; mouse; osteoblast; single cell RNA-seq.

PubMed Disclaimer

Conflict of interest statement

NO No competing interests declared

Figures

Figure 1.
Figure 1.. MALP cells and the formation of bone and blood vessels in the bone marrow (Zhong et al., 2020).
Schematic view of bone (grey) and bone marrow (orange). Bone marrow contains many different types of mesenchymal stromal cells: these include mesenchymal progenitor cells (purple), pre-osteoblasts (green), and pre-adipocytes (red). Mesenchymal progenitor cells and pre-osteoblasts can both give rise to the osteoblasts that line the bone surface (smooth yellow cells) and to the osteocytes that are embedded within the bone (jagged yellow cells). A MALP cell is type of pre-adipocyte, and MALP cells that express a hormone called adiponectin have important roles in: i) maintaining the marrow vasculature (arrow-ended red lines); ii) preventing mesenchymal progenitor cells from differentiating into osteoblasts (flat-ended red lines).
See this image and copyright information in PMC

Comment on

References

    1. Baccin C, Al-Sabah J, Velten L, Helbling PM, Grünschläger F, Hernández-Malmierca P, Nombela-Arrieta C, Steinmetz LM, Trumpp A, Haas S. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology. 2020;22:38–48. doi: 10.1038/s41556-019-0439-6. - DOI - PMC - PubMed
    1. Baryawno N, Przybylski D, Kowalczyk MS, Kfoury Y, Severe N, Gustafsson K, Kokkaliaris KD, Mercier F, Tabaka M, Hofree M, Dionne D, Papazian A, Lee D, Ashenberg O, Subramanian A, Vaishnav ED, Rozenblatt-Rosen O, Regev A, Scadden DT. A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia. Cell. 2019;177:1915–1932. doi: 10.1016/j.cell.2019.04.040. - DOI - PMC - PubMed
    1. Matsushita Y, Nagata M, Kozloff KM, Welch JD, Mizuhashi K, Tokavanich N, Hallett SA, Link DC, Nagasawa T, Ono W, Ono N. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nature Communications. 2020;11:332. doi: 10.1038/s41467-019-14029-w. - DOI - PMC - PubMed
    1. Ono N, Ono W, Nagasawa T, Kronenberg HM. A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones. Nature Cell Biology. 2014;16:1157–1167. doi: 10.1038/ncb3067. - DOI - PMC - PubMed
    1. Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I. The bone marrow microenvironment at single-cell resolution. Nature. 2019;569:222–228. doi: 10.1038/s41586-019-1104-8. - DOI - PMC - PubMed