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. 2020 Jul;75(7):1822-1824.
doi: 10.1111/all.14360. Epub 2020 May 25.

SARS-CoV-2 immunogenicity at the crossroads

Fariba Karamloo  1 , Renate König  2   3
Affiliations

SARS-CoV-2 immunogenicity at the crossroads

Fariba Karamloo et al. Allergy. 2020 Jul.
No abstract available

Keywords: infections; inflammation; lung diseases other than asthma and COPD; vaccines; virus.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Schematic of SARS‐CoV and SARS‐CoV‐2 spike protein. Coronavirus spike protein harbors the S1 and S2 subunits, which are cleaved at the S1/S2 boundary and the S2′ cleavage site, as indicated by arrows. SARS‐CoV‐2 spike protein harbors a polybasic furin cleavage sequence (PRRARS) with an insertion of four amino acid residues distinct from SARS‐CoV and other SARS‐like viruses. The receptor‐binding domain (RBD) is indicated in dark green. Predicted dominant B‐ and T‐cell epitope regions are indicated as red and blue bars, respectively, adapted from Grifoni et al. The two immunodominant B‐cell linear epitopes identified by Poh et al are indicated as yellow bars
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