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Review
. 2020 Dec;1481(1):127-138.
doi: 10.1111/nyas.14366. Epub 2020 May 13.

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

Miles J Klimara  1 , Derrick R Randall  2 , Jacqueline Allen  3 , Edgar Figueredo  4 , Nikki Johnston  5   6
Affiliations
Review

Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations

Miles J Klimara et al. Ann N Y Acad Sci. 2020 Dec.

Abstract

Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric upper and lower airway diseases. However, the diagnosis of proximal reflux-associated disease remains challenging due to evolving clinical criteria and institutional and regional variances in diagnostic practices. Evidence suggests that nonacidic contents of reflux may serve as both pathologic mediators of and biomarkers for reflux in the upper airway. Furthermore, they offer potential pharmaceutical and surgical intervention targets and are the focus of novel clinical diagnostic tools currently under investigation.

Keywords: airway; cough; extraesophageal reflux (EER); laryngopharyngeal reflux (LPR); pepsin; reflux.

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References

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