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Case Reports
. 2020 Oct 6;24(4):507-509.
doi: 10.5935/1518-0557.20190093.

A successful pregnancy following recurrent implantation failure with clinical laboratory strategy

Roshan Nikbakht  1 , Parvin Dorfeshan  2 , Narjes Dibavand  1 , Mahsa Afrough  3
Affiliations
Case Reports

A successful pregnancy following recurrent implantation failure with clinical laboratory strategy

Roshan Nikbakht et al. JBRA Assist Reprod. .

Abstract

In treatment cycles of in vitro fertilization (IVF), 15% of the oocytes are immature and in the germinal vesicle (GV) phase. In rare occasions, more than 50% of the oocytes of a patient in a cycle are immature. Selecting fertility treatment for patients in this situation can be very challenging. The patient described in this report was a 35-year-old woman with primary infertility for 10 years. She had undergone fertility treatment six times, with no success. In her cycles, more than 50% of the oocytes were immature and in the GV phase. To address the situation, we developed a coordinated protocol involving medical and embryology procedures, analyzed the patient's medical records, and looked into the reasons of prior treatment failure. The development of a special and coordinated effort - instead of having medical and embryology teams working in isolation - proved efficient at providing better outcomes to the patient.

Keywords: assisted reproductive technology; in vitro fertilization; infertility.

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References

    1. Bagheri-Lankarani N, Zarei F, Zandi M, Omani Samani R, Karimi M. The Experiences of Women Fertilized through Egg Donation During Their Treatment Process. Evid Based Care J. 2016;6:63–70.
    1. Beck-Fruchter R, Weiss A, Lavee M, Geslevich Y, Shalev E. Empty follicle syndrome: successful treatment in a recurrent case and review of the literature. Hum Reprod. 2012;27:1357–1367. doi: 10.1093/humrep/des037. - DOI - PubMed
    1. Cha KY, Chian RC. Maturation in vitro of immature human oocytes for clinical use. Hum Reprod Update. 1998;4:103–120. doi: 10.1093/humupd/4.2.103. - DOI - PubMed
    1. Chian RC, Buckett WM, Tan SL. In-vitro maturation of human oocytes. Reprod Biomed Online. 2004;8:148–166. doi: 10.1016/S1472-6483(10)60511-1. - DOI - PubMed
    1. Gardner DK, Sheehan CB, Rienzi L, Katz-Jaffe M, Larman MG. Analysis of oocyte physiology to improve cryopreservation procedures. Theriogenology. 2007;67:64–72. doi: 10.1016/j.theriogenology.2006.09.012. - DOI - PubMed

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