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Review
. 2020 Jun;41(2):269-280.
doi: 10.1016/j.ccm.2020.02.011. Epub 2020 Apr 16.

Breaking the Impasse: Advances in Treatment of Small Cell Lung Cancer

Andreas Saltos  1 , Scott Antonia  2
Affiliations
Review

Breaking the Impasse: Advances in Treatment of Small Cell Lung Cancer

Andreas Saltos et al. Clin Chest Med. 2020 Jun.

Abstract

Small cell lung cancer (SCLC) is an aggressive malignancy and carries a poor prognosis with limited effective treatments in the advanced setting. SCLC is characterized by a high tumor mutation burden and alterations in Notch signaling and DNA damage repair pathways, providing rationale for the use of immunotherapy and targeted therapies. Immunotherapies have led to the most significant advances in treating SCLC in decades, and several promising targeted approaches have emerged from the increased understanding of the biology of SCLC. However, responses to these novel approaches are far from universal, and efforts to refine these therapies are ongoing.

Keywords: DLL-3; DNA damage repair; Immunotherapy; Small cell lung cancer.

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Conflict of interest statement

Disclosure A. Saltos: Nothing to disclose. S. Antonia: Participated in advisory boards for AstraZeneca/MedImmune, Boehringer Ingelheim, Bristol-Myers Squibb, Merck, and Novartis, and scientific advisory boards for CBMG and Memgen outside the submitted work.

MeSH terms