Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 May 13;5(1):69.
doi: 10.1038/s41392-020-0180-4.

Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity

Caiyun Fu  1
Affiliations
Comment

Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity

Caiyun Fu. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
GSDME cleavage by GzmB/caspase 3 promoted pore formation to induce pyroptosis and suppress tumour growth through the enhancement of anti-tumour adaptive immunity
See this image and copyright information in PMC

Comment on

References

    1. Zhang Z, et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 2020;579:415–420. doi: 10.1038/s41586-020-2071-9. - DOI - PMC - PubMed
    1. Wang Q, et al. A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature. 2020;579:421–426. doi: 10.1038/s41586-020-2079-1. - DOI - PubMed
    1. Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem. Sci. 2017;42:245–254. doi: 10.1016/j.tibs.2016.10.004. - DOI - PubMed
    1. Ding J, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature. 2016;535:111–116. doi: 10.1038/nature18590. - DOI - PubMed
    1. Xia X, et al. The role of pyroptosis in cancer: pro-cancer or pro-“host”? Cell Death Dis. 2019;10:650–662. doi: 10.1038/s41419-019-1883-8. - DOI - PMC - PubMed

Publication types