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. 2020 Jun 11;181(6):1194-1199.
doi: 10.1016/j.cell.2020.05.016. Epub 2020 May 13.

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jean-Laurent Casanova  1 , Helen C Su  2 ; COVID Human Genetic Effort
Collaborators, Affiliations

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jean-Laurent Casanova et al. Cell. .

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

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Conflict of interest statement

Declaration of Interests Helen Su holds Adjunct Faculty position in the Department of Pathology and Laboratory Medicine, University of Pennsylvania.

Figures

Figure 1
Figure 1
Monogenic Causes of Susceptibility or Resistance to SARS-CoV-2 Infection In the naive general population (black), a proportion of people become symptomatic (purple) when infected. Severe cases (red) tend to occur in the elderly or in those patients having co-morbidities. However, rare “idiopathic” severe cases can occur in the young without co-morbidities, and these are hypothesized to represent patients with monogenic causes. A proportion of people remain asymptomatic (blue) when infected. In some instances, these may be people who remain resistant to infection (orange), who can be identified by their remaining seronegative despite heavy or repeated exposures to the virus. Created with BioRender.
See this image and copyright information in PMC

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