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. 2020 May 6;5(3):602-610.
doi: 10.1016/j.bioactmat.2020.04.006. eCollection 2020 Sep.

A new antimicrobial compound from the leaves of Dodonaea viscosa for infectious diseases

Basma Mubarak Hamed Al Bimani  1 , Mohammad Amzad Hossain  1
Affiliations

A new antimicrobial compound from the leaves of Dodonaea viscosa for infectious diseases

Basma Mubarak Hamed Al Bimani et al. Bioact Mater. .

Erratum in

Abstract

The main aim of this research work was to isolate and characterize the antimicrobial compounds that can be extracted from the leaves of Dodonaea viscosa (D. viscosa) and to assess their antimicrobial potency by established in-vitro agar diffusion method. The methanol extract was liquefied and fractioned by using a separatory funnel and organic solvents having different polarities. The agar diffusion technique was used to assess the antimicrobial potency of extracts and pure compounds against 5 g (+and -) microbial strains. Antimicrobial potency results showed that all extracts and isolated pure compounds provided significant antimicrobial potency against the applied microbial strains. The highest activity chloroform extract was analysed by column chromatography (CC) for the isolation of antimicrobial compounds. The structure of the isolated compounds was characterized based on 1D, 2D NMR and MS spectra. In conclusion, purest compounds might be useful as a remedy for infectious diseases.

Keywords: Antimicrobial compounds; Antimicrobial potency; Chromatography; Dodonaea viscosa; MS; NMR; Soxhlet.

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Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Chemical structure of compound 1 and compound 2.
Fig. 2
Fig. 2
1H NMR spectra of Compound 1.
Fig. 3
Fig. 3
13C NMR spectra of Compound 1.
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Fig. 4
DEPT 90 and 135 spectrum of compound 1.
Fig. 5
Fig. 5
COSY spectrum of compound 1.
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Fig. 6
NOSEY spectrum of compound 1.
Fig. 7
Fig. 7
COSY and HMBC correlation of compound 1.
See this image and copyright information in PMC

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