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. 2020 Feb 22;5(5):737-741.
doi: 10.1016/j.ekir.2020.02.1026. eCollection 2020 May.

1-Methyluric Acid Nephropathy

Jeremy Zaworski  1 , Elise Bouderlique  1 , Dany Anglicheau  2 , Jean-Paul Duong Van Huyen  3 , Viviane Gnemmi  4   5 , Jean-Baptiste Gibier  4   5 , Yann Neugebauer  6 , Jean-Philippe Haymann  1 , Dominique Bazin  7 , Vincent Frochot  1 , Michel Daudon  1 , Emmanuel Letavernier  1
Affiliations

1-Methyluric Acid Nephropathy

Jeremy Zaworski et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Crystals of 1-methyluric acid in urine and kidney biopsies. (a) Crystalluria, 1-methyluric acid crystals in urine (case 1) were round-shaped with a central maltese cross. Bar = 25 μm. (b) Crystals of 1-methyluric acid were sometimes inside macrophagic cells in urine. Bar = 25 μm. (c,d) Periodic acid–Schiff staining. Intratubular crystallites (case 2) were brown/greenish and refractive in polarized light. Bar = 25 μm. (e) MUC1 immunostaining (red) revealed that crystals were mostly observed within distal tubules and not in the proximal tubules stained in green by lectin Lotus Tetragonolobus. Bar = 25 μm. (f) Scanning electron microscopy evidenced massive and poorly organized crystallites in renal tubules. Bar = 25 μm. (g) Fourier-transform infrared reflectance spectrum evidencing the presence of 1-methyl uric acid in kidney biopsies. (h) Transmittance Fourier-transform infrared spectroscopic analysis reference spectrum obtained from a 1-methyl uric acid stone. (i) Uric acid (dihydrate) transmittance Fourier-transform infrared spectroscopic analysis reference spectrum obtained from a kidney stone, showing differences with 1-methyl uric acid spectrum.
Figure 2
Figure 2
Main metabolites of caffeine found in the urine. XO, xanthine oxidase; CYP1A2, cytochrome P 450 1A2; 1,3 DMX, 1,3 dimethylxanthine (theophylline); 1,7 DMX, 1,7 dimethylxanthine; 1 MX, 1 methylxanthine; 1 MU, 1 methyluric acid.
See this image and copyright information in PMC

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