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. 2020 Jun;47(3):187-188.
doi: 10.1007/s10928-020-09689-x. Epub 2020 May 13.

Hydroxychloroquine and azithromycin as potential treatments for COVID-19; clinical status impacts the outcome

Malek Okour  1 , Mahmoud Al-Kofahi  2 , Daren Austin  3
Affiliations

Hydroxychloroquine and azithromycin as potential treatments for COVID-19; clinical status impacts the outcome

Malek Okour et al. J Pharmacokinet Pharmacodyn. 2020 Jun.
No abstract available

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Figures

Fig. 1
Fig. 1
Predicted Probability of Positive-PCR across treatment days at average hydroxychloroquine concentration. *Points are observed data reported in Gautret et al. study. Solid lines and shaded areas are predicted probability with 95% confidence interval. ASYM asymptomatic, AZITH azithromycin co-treatment, HCQ hydroxychloroquine, URTI upper respiratory tract infection, LRTI lower respiratory tract infection; Legend: 0 means the respective drug is not taken while 1 means the respective drug is taken
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References

    1. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;20:20. doi: 10.1016/j.ijantimicag.2020.105949:105949. - DOI - PMC - PubMed
    1. Lim HS, Im JS, Cho JY, Bae KS, Klein TA, Yeom JS, Kim TS, Choi JS, Jang IJ, Park JW. Pharmacokinetics of hydroxychloroquine and its clinical implications in chemoprophylaxis against malaria caused by Plasmodium vivax. Antimicrob Agents Chemother. 2009;53(4):1468–1475. doi: 10.1128/AAC.00339-08. - DOI - PMC - PubMed

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