Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jun 25;58(7):1029-1036.
doi: 10.1515/cclm-2020-0502.

COVID-19: progression of disease and intravascular coagulation - present status and future perspectives

Job Harenberg  1 , Emmanuel Favaloro  2
Affiliations
Free article
Review

COVID-19: progression of disease and intravascular coagulation - present status and future perspectives

Job Harenberg et al. Clin Chem Lab Med. .
Free article

Abstract

The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human society. We focus this article on (a) developments for improvement of diagnosis of specific SARS-CoV-2 virus, (b) laboratory changes in the immunologic and coagulation system, (c) therapeutic options for anticoagulant treatment of seriously affected patients and (d) on the perspectives through improvement of diagnostic and therapeutic medical procedures.

Keywords: COVID-19; D-dimer; SARS-CoV-2; antibodies; anticoagulation; autopsy; coagulation parameters; disseminated intravascular coagulation; heparin; low-molecular-weight heparin; pulmonary embolism; thrombosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Iba T, Levy JH. Derangement of the endothelial glycocalyx in sepsis. J Thromb Haemost 2019;17:283–94.
    1. Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet 2020;395:1417–8.
    1. Rizzo P, Vieceli Dalla Sega F, Fortini F, Marracino L, Rapezzi C, Ferrari R. COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm? Basic Res Cardiol 2020;115:31.
    1. Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 2020; pii: S0085-2538(20)30369-0. doi: 10.1016/j.kint.2020.04.003. [Epub ahead of print].
    1. Ye M, Ren Y, Lv T. Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun 2020; pii: S0889-1591(20)30465-7. doi: 10.1016/j.bbi.2020.04.017. [Epub ahead of print].

MeSH terms

Substances

LinkOut - more resources