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Review
. 2020 Jun 25;58(7):1029-1036.
doi: 10.1515/cclm-2020-0502.

COVID-19: progression of disease and intravascular coagulation - present status and future perspectives

Job Harenberg  1 , Emmanuel Favaloro  2
Affiliations
Free article
Review

COVID-19: progression of disease and intravascular coagulation - present status and future perspectives

Job Harenberg et al. Clin Chem Lab Med. .
Free article

Abstract

The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human society. We focus this article on (a) developments for improvement of diagnosis of specific SARS-CoV-2 virus, (b) laboratory changes in the immunologic and coagulation system, (c) therapeutic options for anticoagulant treatment of seriously affected patients and (d) on the perspectives through improvement of diagnostic and therapeutic medical procedures.

Keywords: COVID-19; D-dimer; SARS-CoV-2; antibodies; anticoagulation; autopsy; coagulation parameters; disseminated intravascular coagulation; heparin; low-molecular-weight heparin; pulmonary embolism; thrombosis.

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