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Editorial
. 2020 Mar 6;5(5):572-574.
doi: 10.1016/j.ekir.2020.02.1033. eCollection 2020 May.

Complement Pathways in Membranous Nephropathy: Complex and Multifactorial

Vesna Brglez  1   2 , Sonia Boyer-Suavet  1   2 , Barbara Seitz-Polski  1   2   3   4
Affiliations
Editorial

Complement Pathways in Membranous Nephropathy: Complex and Multifactorial

Vesna Brglez et al. Kidney Int Rep. .
No abstract available

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Figures

Figure 1
Figure 1
Complement system in patients with membranous nephropathy. Classical and lectin pathways are activated following an immune trigger, whereas the alternative pathway is constitutively activated at low level. Classical, lectin, and alternative pathways converge on C3, eventually forming a membrane attack complex. Studies arguing for the predominance of each pathway are cited in rectangles., , , , , Spectral counts from Ravindran et al. are presented as a heat map for each protein studied. Inhibitors available or in clinical trials targeting different complement proteins and complement-regulating proteins are listed next to their targets. MASP, mannan-binding lectin-associated serine protease; MBL, mannose-binding lectin; FH, complement factor H.
See this image and copyright information in PMC

Comment on

  • Proteomic Analysis of Complement Proteins in Membranous Nephropathy.
    Ravindran A, Madden B, Charlesworth MC, Sharma R, Sethi A, Debiec H, Cattran D, Fervenza FC, Smith RJ, Ronco P, Sethi S. Ravindran A, et al. Kidney Int Rep. 2020 Jan 30;5(5):618-626. doi: 10.1016/j.ekir.2020.01.018. eCollection 2020 May. Kidney Int Rep. 2020. PMID: 32405583 Free PMC article.

References

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