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Review
. 2020 Jun;21(6):315-318.
doi: 10.1111/1751-2980.12883.

Role of non-inflammatory factors in intestinal fibrosis

Jin Fang Zhao  1   2 , Fang Mei Ling  3 , Jun Rong Li  3 , Yi Dong Chen  3 , Liang Huang  4 , Liang Ru Zhu  3
Affiliations
Review

Role of non-inflammatory factors in intestinal fibrosis

Jin Fang Zhao et al. J Dig Dis. 2020 Jun.

Abstract

Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD), resulting in strictures and ultimately obstruction, which is a significant clinical problem. Fibrosis is mainly triggered by local chronic inflammation and occurs when excessive extracellular matrix deposition is caused by activated mesenchymal cells. Despite the advance of anti-inflammatory therapies in IBD, the incidence and preventive strategies of intestinal fibrosis and strictures in IBD have not significantly changed over time. This shows that inflammation is necessary for fibrosis, but it does not necessarily affect the fibrotic progression. This review summarizes current knowledge about the non-inflammatory mechanisms implicated in the gut fibrotic process of IBD, which may pave the way for new mechanisms and anti-fibrotic therapies.

Keywords: extracellular matrix; inflammatory bowel diseases; intestinal fibrosis; mesenchymal cell.

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References

REFERENCES

    1. Rieder F, Zimmermann EM, Remzi FH, Sandborn WJ. Crohn's disease complicated by strictures: a systematic review. Gut. 2013;62(7):1072-1084.
    1. Fiocchi C, Lund PK. Themes in fibrosis and gastrointestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2011;300(5):G677-G683.
    1. de Bruyn JR, Meijer SL, Wildenberg ME, Bemelman WA, van den Brink GR, D'Haens GR. Development of fibrosis in acute and longstanding ulcerative colitis. J Crohns Colitis. 2015;9(11):966-972.
    1. Silverstein MD, Loftus EV, Sandborn WJ, et al. Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort. Gastroenterology. 1999;117(1):49-57.
    1. Rieder F, Fiocchi C, Rogler G. Mechanisms, management, and treatment of fibrosis in patients with inflammatory bowel diseases. Gastroenterology. 2017;152(2):340-350.e6.

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