Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 16;323(23):2424-2425.
doi: 10.1001/jama.2020.8438.

Asymptomatic Seroconversion of Immunoglobulins to SARS-CoV-2 in a Pediatric Dialysis Unit

David S Hains  1 , Andrew L Schwaderer  1 , Aaron E Carroll  1 , Michelle C Starr  1 , Amy C Wilson  1 , Fatima Amanat  2 , Florian Krammer  2
Affiliations

Asymptomatic Seroconversion of Immunoglobulins to SARS-CoV-2 in a Pediatric Dialysis Unit

David S Hains et al. JAMA. .

Abstract

This case series describes subclinical development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in some patients and health care workers in a pediatric dialysis unit after contact with a seropositive patient.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Schwaderer reported receiving grants from Eli Lilly Foundation and the National Institutes of Health. Dr Krammer reported that a patent to The Icahn School of Medicine at Mount Sinai is in the process of licensing assays based on the assays described herein to commercial entities and that the school of medicine has filed for patent protection, pending and licensed. No other authors reported disclosures.

Figures

Figure.
Figure.. Cumulative Seroconversion (Development of SARS-CoV-2 IgM or IgG Antibodies) Rates by Week of Study in Patients Receiving Dialysis and Health Care Workers
Individuals were considered seropositive based on the study day in which they were first found to be seropositive for IgM, IgG, or both. SARS-CoV-2 indicates severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

References

    1. Su K, Ma Y, Wang Y, et al. . How we mitigate and contain COVID-19 outbreak in hemodialysis center (HD): lessons and experiences. Infect Control Hosp Epidemiol. Published online April 23, 2020. doi:10.1017/ice.2020.161 - DOI - PMC - PubMed
    1. Kliger AS, Silberzweig J. Mitigating risk of COVID-19 in dialysis facilities. Clin J Am Soc Nephrol. 2020;15(5):707-709. doi:10.2215/CJN.03340320 - DOI - PMC - PubMed
    1. Stadlbauer D, Amanat F, Chromikova V, et al. . SARS-CoV-2 seroconversion in humans: a detailed protocol for a serological assay, antigen production, and test setup. Curr Protoc Microbiol. 2020;57(1):e100. doi:10.1002/cpmc.100 - DOI - PMC - PubMed
    1. Luo L, Ren L, Yang S, et al. . Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clin Infect Dis. Published online March 21, 2020. doi:10.1093/cid/ciaa310 - DOI - PMC - PubMed

Publication types

MeSH terms